NFL Odds for Seahawks vs. 49ers: Betting System Pick & Prediction for Saturday’s Spread

NFL Odds: Seahawks vs. 49ers

*Odds as of Saturday afternoon

The Seattle Seahawks and San Francisco 49ers will meet for the third time this season with Seattle looking for its first win against its NFC West rivals.

San Francisco topped Seattle, 27-7, back in Week 2, then completed its sweep with a 21-13 victory in Week 15.

The latest NFL odds are suggesting another relatively easy win for the 49ers today, but what does that mean for bettors?

Is the best NFL pick to lay the points with the Niners or bet on the Seahawks to keep this game close?

Or with wet and windy weather in the latest forecast, is the smartest NFL prediction on the Seahawks vs. 49ers over/under instead?

With the help of the Action Network’s PRO betting tools, let’s examine the NFL pick that sharps are making, which also matches a betting system with a 65% against-the-spread (ATS) win rate dating back to 2004.

NFL Pick: Seahawks vs. 49ers

Seahawks vs. 49ers is shaping up as a classic Pros vs. Joes situation.

Sixty-seven percent of spread tickets are laying it with San Francisco to this point, yet the line has dipped from Seattle +10.5 to +9.5 (click here for live NFL odds).

Why? Because of wagers from respected bettors.

While the majority of bettors have gotten down on the 49ers, the small percentage of those taking the Seahawks have caught the attention of oddsmakers – and for good reason.

Seattle is a match for the Action Network’s Bet Against Public Playoffs PRO System, which has produced a 31-17-1 (65%) ATS record.

It identifies underdogs of at least 5.5 points in lower-total games that receive fewer than 50% of the tickets – just like the Seahawks.

Pick: Seahawks +9.5

Bet Seattle Instantly at FanDuel With QuickSlip