Three underdogs don’t need the points on Sunday of NFL Week 1. We’ve bookmarked a trio of sides primed for an upset right out the gates.
PRO Systems feature a backtested system (22% ROI) strictly for NFL upset predictions. The trend already highlighted several Week 1 NFL matchups in which betting the underdog to win outright is a smart play for Sunday.
The top NFL upset picks for Week 1 from our premium PRO System consider factors like spread range, over/under, division and more.
The best time to capitalize on this angle is early in the season, when team strengths are still uncertain.
These are the top betting choices to pull off an upset in Week 1, supported by nothing but reliable data.
NFL Upset Predictions, Moneyline Picks for Week 1
It’s fun to root for upsets.
However, don’t just blindly throw darts at plus-money picks for NFL Sunday; there’s a certain method to picking the best NFL upsets, and our PRO System guides us to a handful of worthwhile moneyline predictions.
Known as the “Early Season Upsets” angle, this NFL betting strategy hinges on betting divisional underdogs on the moneyline within the first three weeks, if they are 0-5.5 against the spread.
The model theory is that unpredictable, early-season performances and divisional knowledge between foes increase the likelihood of upsets.
Although the PRO System boasts just a 50% win rate, all predictions made at plus-money odds has piled up a ton of loot in the long run.
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Early Season Upsets flagged these three teams ripe for an upset Sunday of NFL Week 1.
Panthers vs. Saints Moneyline Pick
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The Panthers are a perfect ‘ugly’ dog, with only one way to go after finishing the worst team against the spread.
Bryce Young and Carolina to upset David Carr and the Saints also marks the best payout of any moneyline play recommended by the PRO System for Sunday.
Shop our NFL odds page for the best price, no matter which bet you make on Sunday’s Panthers vs. Saints game.
PRO System Pick: Panthers Moneyline
Texans vs. Colts Moneyline Pick
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CJ Stroud vs. Anthony Richardson headlines a sweet AFC South matchup, which typically favors sides like the Colts, based on spread range.
PRO System Pick: Colts Moneyline
Raiders vs. Chargers Moneyline Pick
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The final model prediction for Sunday of NFL Week 1 is the Raiders to spoil Chargers head coach Jim Harbaugh’s regular-season debut.
PRO System Pick: Raiders Moneyline
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