The 2022 NFL Thanksgiving slate is nearly upon us, starting with Bills vs. Lions at 12:30 p.m. ET, followed by Giants vs. Cowboys at 4:30 p.m. ET and Patriots vs. Vikings at 8:20 p.m. ET.
NFL action is ingrained as a Thanksgiving tradition, making it a very popular football betting holiday as well.
NFL bettors will flood Thursday’s Thanksgiving tripleheader, and the Action Network’s PRO betting tools are already showing the most valuable positions to take on each of today’s three games.
So let’s look at the smartest Thanksgiving bets, including the NFL pick that sharps are making for Bills vs. Lions, a Giants vs. Cowboys system prediction with a 60% win rate and which Patriots vs. Vikings side experts are betting.
NFL Picks for Thanksgiving
*NFL odds as of Thursday morning
Bills vs. Lions NFL Pick
12:30 p.m. ET | CBS
The Bills vs. Lions total opened at 52.5 and wiseguys have pounded the over throughout the past couple of days.
Action Labs’ Bet Signals have tracked four Steam Moves on the over to this point, tipping exactly how the pros are playing this matchup.
In addition, our NFL public betting data shows that 76% of the money wagered on this total has come in on the over, leaving little doubt as to why this line has climbed to a consensus of 54.5.
With that said, DraftKings still has this total listed at 54, so be sure to visit the Action Network’s NFL Live Odds Page to find the best number possible before getting down on this matchup.
PRO Report Pick: Over 54
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Giants vs. Cowboys NFL Pick
4:30 p.m. ET | FOX
The New York Giants turned back into pumpkins last weekend against the Detroit Lions and now see themselves as nearly 10-point underdogs against the Dallas Cowboys on Thanksgiving Day.
But when it comes to solely value, bettors should be turning their attention toward the total.
Because this is a divisional matchup, Giants vs. Cowboys is a match for our Divisional Unders PRO Betting System, which has produced a record of 228-153-5 (60%) since 2005.
Just like Bills vs. Lions above, there is variance across the market regarding the Giants vs. Cowboys total, so be sure to shop around before betting this under.
PRO Report Pick: Under 45.5
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Patriots vs. Vikings NFL Pick
8:20 p.m. ET | NBC
The Thanksgiving nightcap has the Patriots traveling to Minnesota to take on the Vikings and one of our top NFL bettors has already wagered on New England and the points.
Further, 52% of the loot has come in on the Patriots as well, but on just 32% of the tickets, suggesting that the bigger bets are also landing on the underdogs in this matchup.
PRO Report Pick: Patriots +2.5