NFL Odds: Colts vs. Broncos
| Colts Odds | +3.5 |
| Broncos Odds | -3.5 |
| Over/Under | 42 |
| Date | Thursday, Oct. 6 |
| Time | 8:15 p.m. ET |
| Channel | Amazon Prime Video |
*NFL odds as of Thursday morning
Both the Indianapolis Colts and Denver Broncos landed new starting quarterbacks over the offseason, and on Thursday Night both will be relying on their signal-callers to prevent their teams from heading into Week 6 with losing records.
NFL odds for Thursday Night Football have the Broncos as 3- to 3.5-point favorites over the Colts depending on the sportsbook, with the over/under sitting at 42.
In addition, news broke on Wednesday that Indianapolis will be without its best player, Jonathan Taylor, due to an ankle injury, which will clearly make it harder for the Colts on the offensive side of the ball.
With this in mind, what is the smartest way to bet Colts vs. Broncos on Thursday Night Football?
According to the market’s sharpest NFL bettors, the answer is an easy one.
NFL Pick: Colts vs. Broncos
In the case of Colts vs. Broncos, the sharp play is the obvious play.
Even with quarterback Russell Wilson under center, Denver has struggled mightily on the offensive side of the ball.
Now take Taylor away from the Colts offense, and we have the makings of a low-scoring game, which is exactly what the wiseguys are banking on.
The Thursday Night Football total opened at 43.5, but has been pushed down to 42 (click here for live NFL odds) as bettors reacted to news of Taylor’s absence in a matchup that was already very likely to be a grind offensively.
PRO Report Pick: Under 42
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