The Miami Dolphins and Detroit Lions will face off in Week 2 of the NFL Preseason. Kickoff is set for 1:00 p.m. ET from Ford Field in Detroit, Michigan. The game will broadcast live on NFL Network.
The Dolphins are 2.5-point favorites over the Lions on the spread (Dolphins -2.5), with the over/under set at 37 total points. Miami is a -130 favorite to win outright, while Detroit is +110 to pull off the upset.
Let’s get into my Dolphins vs Lions predictions and NFL Preseason picks for Saturday, August 16.
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Dolphins vs Lions Odds
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- Dolphins vs Lions spread: Dolphins -2.5
- Dolphins vs Lions over/under: 37 total points
- Dolphins vs Lions moneyline: Dolphins -130, Lions +110
- Dolphins vs Lions best bet: Lions ML (+110)
My Lions vs Dolphins best bet is on Detroit moneyline, with the best odds currently available at BetMGM. For all of your NFL bets, be sure to find the best lines by using our live NFL odds page.
Dolphins vs Lions NFL Preseason Preview, Picks
In Week 2 of the NFL preseason, teams often test depth while beginning to evaluate potential starters, creating a unique window where small underdogs can outperform market expectations, which may be the case for the Lions in today’s matchup against the Dolphins.
This system focuses on games with a spread between even and -5.5 five during Week 2 of the preseason, capitalizing on inconsistent quarterback rotations and coaching priorities that can lead to outright wins for small ‘dogs.
Since teams may be less motivated to protect a lead and more interested in evaluating players late in games, the volatility and tight spreads can create opportunities for underdogs to secure victories.
By isolating these conditions, the system leverages a market inefficiency tied to the second week of preseason when public perception does not fully align with how games play out on the field, resulting in a positive return despite a modest win rate.
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Dolphins vs Lions Betting Prediction
- Lions Moneyline (+110)
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Spread
I’m betting on Detroit to cover this spread.
Moneyline
I have no play on the Dolphins vs Lions moneyline.
Over/Under
I’m not betting the Lions vs Dolphins over/under.
My Pick: Lions +2.5
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Dolphins vs Lions Betting Trends
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NFL Weather
[gameforecast league=”nfl” gameid=”256810″ date=”20250816″][/gameforecast]
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