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49ers vs. Seahawks Odds: Opening Week 12 Spread, Total for Thanksgiving

49ers vs. Seahawks Odds

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The 49ers are back to their dominant ways after dropping three-straight games before their bye week. They beat up on the Jaguars 34-3 two weeks ago, and then won 27-14 Sunday against the Buccaneers. They failed to cover, though, and are 1-4 against the spread over their last five games.

It’s been nine years since the Niners last played on Thanksgiving, falling 19-3 against these very same Seahawks. The 49ers have a 30-20 edge in the all-time series against their archrivals. They’ve won three-straight against them including last year’s playoff win, doing so by an average of 15.3 points.

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Seattle blew a 16-7 lead to their division foe Rams, but they may have lost even more as Geno Smith (elbow) and Kenneth Williams (oblique) were injured. They now face a quick turnaround against another NFC West foe in the 49ers.

The Seahawks are 2-2 all-time on Thanksgiving, and this marks their first game since 2014 in the aforementioned win over the 49ers. They also return home where they’re 4-1 straight up but 2-3 against the spread. Meanwhile, the over is 3-2 at Lumen Field and has hit in two straight.

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