ncaab-picks-villanova-vs-usc-4-3-2025

Villanova vs USC Prediction Tonight | Basketball Models Best Bet

The Final Four is near! But first, bettors have a chance to lock in a big-time value play Thursday in the CBC.

Tonight’s college basketball odds feature a three-game slate. The hot ticket to bet and pick to make is in Villanova vs. USC, set for 9:30 p.m. ET.

Our proprietary betting models flagged multiple huge edges on tonight’s college basketball game. Action PRO Projections grade every prediction on a traditional A, B, C scale to determine strength.

Tonight’s Villanova vs. USC prediction is an A+ pick from our hoops data – the best of any pick to make Thursday.

Here’s the sharp side for tonight’s Wildcats vs. Trojans prediction.


Villanova vs. USC Odds

  • Villanova vs. USC spread: Villanova -5.5
  • Villanova vs. USC over/under: 150.5
  • Villanova vs. USC moneyline: Villanova -250, USC +200

Villanova dismantled Colorado in the first round of the CBC, in a game that was never really close. Wooga Poplar and Eric Dixon both topped the 20-point mark in a 19-point Wildcats dispatch and cover.

Not to be outdone, USC is off a 29-point rout of Tulane. Our betting models had a feeling the game would land under the closing total — and it did in the Trojans’ 89-60 win.

Tonight’s pick features a big-time value side after running PRO Projections.

Bettors interested in a plus-money bet Thursday night may want to look into the USC Trojans upsetting the Villanova Wildcats.

In a matchup of two teams fresh off blowout wins, our projections favor the underdog.

USC is a consensus +6 against the spread and +200 on the moneyline. PRO Projections reveal a fair betting line of USC +1.7 and a moneyline price of +114.

Both the spread and moneyline plays are graded A+ for Thursday night hoops. We’ll roll with USC moneyline as our big-time value side.

PRO Projections Pick: USC Moneyline


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