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NCAA Tournament Spread Picks for Ole Miss vs Iowa State, Oregon vs Arizona

Sunday’s top NCAA Tournament spread picks are led by a 71% against-the-spread (ATS) Action PRO Betting System that has cashed seven straight picks.

Below, we’re covering Ole Miss vs. Iowa State (7:45 p.m. ET, truTV) and Oregon vs. Arizona (9:40 p.m. ET, TBS) predictions. Both games fit different, historical betting angles.

As the NCAA Tournament heats up, college basketball fans and bettors alike turn their focus to the crucial second-round games. For those looking to gain an edge, insights from our PRO Systems provide invaluable betting trends.

These proprietary systems are finely tuned with clutch data, designed to help subscribers get a leg up on college basketball picks, especially in high-stakes games like Sunday’s.

Let’s dig in.

NCAA Tournament Spread Picks for Ole Miss vs. Iowa State, Oregon vs. Arizona

Ole Miss vs. Iowa State Spread Pick

Iowa State vs. Ole Miss features a 4-vs-6 matchup, with Iowa State favored by 5.

The Cyclones enter Sunday riding high after a dominant opening performance against Lipscomb, while the Rebels narrowly defeated UNC.

Our 71% spread model, a cornerstone of the PRO Systems, is active for this game.

This model went 3-0 this past weekend and has cashed seven consecutive spread picks dating back to last season.

The “Tournament Formula: Defense, Shooting, Seeding” system recommends backing Iowa State to cover the -5 spread on Sunday.

This model excels at identifying small favorites in tightly contested matchups, focusing on teams with similar shooting and defensive metrics.

Since Iowa State fits this profile perfectly, our college basketball predictions suggest a spread cover is likely.

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The same model cashed on UNC in the First Four, as well as on UCLA and UConn in the Round of 64.

PRO Systems Prediction: Iowa State Against the Spread

[quickslipbasic bookname=”Fanatics” booklogo=”https://assets.actionnetwork.com/573837_FanaticsSportsbook20ALT.png” image=”https://images.actionnetwork.com/blog/2025/03/IMG_1783.jpeg” buttontext=”Tail Iowa State Instantly!” buttonlink=”https://www.scoresandodds.com/all/parlay?quickslip=1&onelink=/5kut/zc69n074?sharedBy=QS_0105&ref=10001″][/quickslipbasic]


Oregon vs. Arizona Basketball Spread Pick

Next, we turn to Oregon vs. Arizona, another compelling matchup. Both teams come off dominant first-round victories, with Oregon routing Liberty, 81-52, and Arizona overpowering Akron, 93-65.

Using our NCAA Tournament Defensive Team PRO System, we find that underdogs coming off a game in which they allowed 60 points or fewer cover the spread 57% of the time in the postseason.

This system highlights Oregon as a strong contender to cover, given their recent defensive improvements and the competitive edge that hot defenses bring to the tournament.

PRO Systems Prediction: Oregon Against the Spread

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Our PRO signals flag far more great picks than our staff could author each day — that’s where Action AI comes in. Using generative AI, signals that hit a high grade threshold are written up into articles that are then vetted and edited by a human to help us get you all the sharp action. Read more about how it works here.


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