college-basketball-predictions-picks-upset-moneyline-projections-odds-1-21-2025 pictured: John Blackwell #25 of the Wisconsin Badgers

College Basketball Predictions, Upset Picks, Betting Projections 1/21

College basketball is about to get a whole lot more interesting here in the next few months.

Fortunately, crafty and savvy insights in PRO have been cranking out big edges since the start of the season. Projections, systems, expert picks, sharp-action data, you name it.

Tonight’s college basketball predictions are all about upset picks.

Our PRO Projections crunched the odds and found three underdogs priced +145, +158 and +750 worth a stab on the moneyline tonight.


College Basketball Predictions, Upset Picks, Betting Projections 1/21

Tonight’s selections tip off at 7 p.m. ET and run through 9:30 p.m. We start with the early games and the spiciest pick of the bunch.

According to the PRO Projections, the biggest upset of the night with an edge is Butler to take down UConn.

Butler is a large underdog against the spread (+13), but our fair number is a single-digit spread vs. UConn.

Also, PRO Projections moneyline is Butler +417. ESPN Bet has the best price on the underdogs, at +750. It’s a strong grade-B edge on the visitors to pull off the upset.

PRO Pick: Butler Moneyline (+750)


Sticking with the 7 p.m. games, Action PRO models flagged Duquesne as a smart pick to beat Dayton.

Duquesne is a three-point underdog, but our numbers make the Dukes the favorites!

Therefore, grabbing Duquesne moneyline is a solid bet. ESPN Bet again has the best odds (+145).

PRO Pick: Duquesne Moneyline (+145)


In the highest-profile game of the night between Wisconsin and UCLA, projections side with Wisconsin.

The Badgers are catching four points on the spread tonight, which is a lot larger than the PRO line of Wisconsin +1.3.

Wisconsin’s loaded with upset potential against Mick Cronin’s Bruins tonight. Moneyline odds are the best at Caesars (+158).

PRO Pick: Wisconsin Moneyline (+158)

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