NBA Best Bets for First Round Playoff Games on Tuesday, April 22

The NBA Playoffs resume with an excellent trio of Game 2s on Tuesday night, with Bucks vs. Pacers and Grizzlies vs. Thunder set to tipoff in the early window, and then Timberwolves vs. Lakers will take center stage later in the evening.

Our staff of basketball betting experts dug into the latest odds and identified 4 NBA picks for tonight’s contests. Continue below for our NBA best bets and predictions for Tuesday, April 22.

NBA Best Bets for First Round Playoff Games: Tuesday, April 22

[quickslipbasic bookname=”BetMGM” booklogo=”https://assets.actionnetwork.com/779359_BetMGM800x200@1x.png” image=”https://images.actionnetwork.com/blog/2025/04/IMG_5224.jpg” buttontext=”Add Our NBA Best Bets to Your Bet Slip Instantly!” buttonlink=”https://switchboard.actionnetwork.com/v2/deeplink?deeplinkId[0]=ML1493756422&deeplinkId[1]=ML1492023761&deeplinkId[2]=ML1495703735&context=qs-articles”][/quickslipbasic]

Game	Time (ET)	Pick
[teammatchup link=”#1″ firstfullname=”Memphis Grizzlies” firstlogo=”https://static.sprtactn.co/teamlogos/nba/100/mem.png” secondfullname=”Oklahoma City Thunder” secondlogo=”https://static.sprtactn.co/teamlogos/nba/100/okc.png”][/teammatchup]	7:30 p.m.	Jalen Williams Over 4.5 Assists
[teammatchup link=”#2″ firstfullname=”Milwaukee Bucks” firstlogo=”https://static.sprtactn.co/teamlogos/nba/100/mil.png” secondfullname=”Indiana Pacers” secondlogo=”https://static.sprtactn.co/teamlogos/nba/100/ind.png”][/teammatchup]	7 p.m.	Bucks +4.5 / Bucks ML
[teammatchup link=”#3″ firstfullname=”Minnesota Timberwolves” firstlogo=”https://images.actionnetwork.com/blog/2023/08/nba-updated-logo-minnesota-timberwolves.png” secondfullname=”Los Angeles Lakers” secondlogo=”https://static.sprtactn.co/teamlogos/nba/100/lal.png”][/teammatchup]	10 p.m.	Nickeil Alexander-Walker Over 11.5 PRA
[teammatchup link=”#4″ firstfullname=”Memphis Grizzlies” firstlogo=”https://static.sprtactn.co/teamlogos/nba/100/mem.png” secondfullname=”Oklahoma City Thunder” secondlogo=”https://static.sprtactn.co/teamlogos/nba/100/okc.png”][/teammatchup]	7:30 p.m.	Jalen Williams Over 9.5 RA
Specific betting recommendations come from the sportsbook offering preferred odds as of writing. Always shop for the best price using our NBA Odds page, which automatically surfaces the best lines for every game.

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[subheader sizedown=”false” text=”Grizzlies vs. Thunder”][/subheader]

[gameheader haspick=”true” picktext=”Jalen Williams Over 4.5 Assists (-120)” league=”nba” awaylogo=”https://static.sprtactn.co/teamlogos/nba/100/mem.png” awayname=”Memphis Grizzlies” awayslug=”memphis-grizzlies” homelogo=”https://static.sprtactn.co/teamlogos/nba/100/okc.png” homename=”Oklahoma City Thunder” homeslug=”oklahoma-city-thunder” date=”Tuesday, April 22″ time=”7:30 p.m. ET” network=”TNT” bookname=”FanDuel” bookprimarylogo=”https://assets.actionnetwork.com/122955_FanDuelSportsBook@1x.jpg” bookreviewslug=”fanduel”][/gameheader]

By Joe Dellera

The Thunder face off against the Grizzlies in a matchup they should be able to control from start to finish. Both of these teams play with pace and continued to do so even in Game 1’s blowout.

Historically, Jalen Williams sees about a 6-minute uptick on his postseason minutes. Barring another blowout, we should see that today. He averaged 5.1 assists per game, including 6.6 against the Grizzlies this season.

When he has played at least 30 minutes, he has cleared this 4.5 assists line in 64% of games.

In Game 1, he recorded 6 assists off of 10 potentials in just 25 minutes. I figure he sees more run today as l’d expect a closer game.
Hartenstein was 4/4 on his passes, but nobody could make a 3-pointer on them. I figure that should even out today.

I expect another strong performance from Jalen Williams as OKC should be able to run on this Grizzlies team.

Pick: Jalen Williams Over 4.5 Assists (-120)

[relatedarticle articleimageurl=”https://images.actionnetwork.com/blog/2025/04/Morant-Williams-NBA.jpg” linktext=”Grizzlies vs. Thunder Prediction, Odds, Pick for NBA Playoffs Game 2 on Tuesday, April 22″ link=”https://www.actionnetwork.com/nba/grizzlies-vs-thunder-prediction-odds-pick-nba-playoffs-game-2-tuesday-april-22-qs”][/relatedarticle]

[teammatchup link=”#1″ shadow=”true” firstfullname=”Memphis Grizzlies” firstlogo=”https://static.sprtactn.co/teamlogos/nba/100/mem.png” secondfullname=”Oklahoma City Thunder” secondlogo=”https://static.sprtactn.co/teamlogos/nba/100/okc.png”][/teammatchup]

[teammatchup link=”#2″ shadow=”true” firstfullname=”Milwaukee Bucks” firstlogo=”https://static.sprtactn.co/teamlogos/nba/100/mil.png” secondfullname=”Indiana Pacers” secondlogo=”https://static.sprtactn.co/teamlogos/nba/100/ind.png”][/teammatchup]

[teammatchup link=”#3″ shadow=”true” firstfullname=”Minnesota Timberwolves” firstlogo=”https://images.actionnetwork.com/blog/2023/08/nba-updated-logo-minnesota-timberwolves.png” secondfullname=”Los Angeles Lakers” secondlogo=”https://static.sprtactn.co/teamlogos/nba/100/lal.png”][/teammatchup]

[teammatchup link=”#4″ shadow=”true” firstfullname=”Memphis Grizzlies” firstlogo=”https://static.sprtactn.co/teamlogos/nba/100/mem.png” secondfullname=”Oklahoma City Thunder” secondlogo=”https://static.sprtactn.co/teamlogos/nba/100/okc.png”][/teammatchup]

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[subheader sizedown=”false” text=”Bucks vs. Pacers”][/subheader]

[gameheader haspick=”true” picktext=”Bucks +4.5 (-110) / Bucks Moneyline (+160)” league=”nba” awaylogo=”https://static.sprtactn.co/teamlogos/nba/100/mil.png” awayname=”Milwaukee Bucks” awayslug=”milwaukee-bucks” homelogo=”https://static.sprtactn.co/teamlogos/nba/100/ind.png” homename=”Indiana Pacers” homeslug=”indiana-pacers” date=”Tuesday, April 22″ time=”7 p.m. ET” network=”NBA TV” bookname=”BetMGM” bookprimarylogo=”https://assets.actionnetwork.com/779359_BetMGM800x200@1x.png” bookreviewslug=”betmgm”][/gameheader]

By Michael Fiddle

I am expecting Dame Lillard back for the Milwaukee Bucks in this game and that to provide a huge boost.

The Bucks were 3-1 in the regular season series between these two teams, and the one loss is the one worth exploring. Dame and Giannis were active, the game was in Indiana, and the Pacers closed as a -1 point favorite. The Bucks had the game in the bag until Haliburton’s game-ending 4-point play to win by 1 point.

What has changed between that March contest and now, so much to move this line 3.5 points? I expect Lillard active and the line to close around 2.5, and thus the Bucks remain an actionable spot.

Pick: Bucks +4.5 (-110) / Bucks Moneyline (+160)

[relatedarticle articleimageurl=”https://images.actionnetwork.com/blog/2025/04/BucksPacersGm2.jpg” linktext=”Bucks vs. Pacers Prediction, Odds, Pick for NBA Playoffs Game 2 on Tuesday, April 22″ link=”https://www.actionnetwork.com/nba/milwaukee-bucks-vs-indiana-pacers-prediction-odds-pick-nba-playoffs-game-2-tuesday-april-22-qs”][/relatedarticle]

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[subheader sizedown=”false” text=”Timberwolves vs. Lakers”][/subheader]

[gameheader haspick=”true” picktext=”Nickeil Alexander-Walker Over 11.5 Points + Rebounds + Assists (-120)” league=”nba” awaylogo=”https://images.actionnetwork.com/blog/2023/08/nba-updated-logo-minnesota-timberwolves.png” awayname=”Minnesota Timberwolves” awayslug=”minnesota-timberwolves” homelogo=”https://static.sprtactn.co/teamlogos/nba/100/lal.png” homename=”Los Angeles Lakers” homeslug=”los-angeles-lakers” date=”Tuesday, April 22″ time=”10 p.m. ET” network=”TNT” bookname=”Fanatics Sportsbook” bookprimarylogo=”https://assets.actionnetwork.com/542724_Fanatics-banner-logo.png” bookreviewslug=”fanatics-sportsbook”][/gameheader]

By Joe Dellera

The Timberwolves look to build on their 1-0 series lead and steal the first two games of this series on the road. One player that should continue to see floor time is Nickeil Alexander-Walker.

NAW played 20 minutes in Game 1, despite shooting just 2/9 from the field. It’s evident that Mike Conley is going to struggle in this series and NAW is someone the Wolves can turn to.

On the season, NAW is averaging 16.3 PRA in about 25 minutes. While he likely is capped around 25, even then he is averaging 12.4 PRA. I think this is a good opportunity for him because of his defensive versatility, and if the shot starts to fall, he could see his minutes increase.

Pick: Nickeil Alexander-Walker Over 11.5 Points + Rebounds + Assists (-120)

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[subheader sizedown=”false” text=”Grizzlies vs. Thunder”][/subheader]

[gameheader haspick=”true” picktext=”Jalen Williams Over 9.5 Rebounds + Assists (-135)” league=”nba” awaylogo=”https://static.sprtactn.co/teamlogos/nba/100/mem.png” awayname=”Memphis Grizzlies” awayslug=”memphis-grizzlies” homelogo=”https://static.sprtactn.co/teamlogos/nba/100/okc.png” homename=”Oklahoma City Thunder” homeslug=”oklahoma-city-thunder” date=”Tuesday, April 22″ time=”7:30 p.m. ET” network=”TNT” bookname=”FanDuel” bookprimarylogo=”https://assets.actionnetwork.com/122955_FanDuelSportsBook@1x.jpg” bookreviewslug=”fanduel”][/gameheader]

By Bryan Fonseca

Jalen Williams has gotten this over in five of his last six matchups against Memphis, including Game 1. In fact, his only under rang in at 9 rebounds + assists.

In these six games, he has had five or more rebounds in all of them, and fell below five assists just once, getting four exactly.

Williams has the right matchup, which will be played at the ideal pace for him to exceed this once more in a likely OKC victory.

Pick: Jalen Williams Over 9.5 Rebounds + Assists (-135)

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