The Baltimore Orioles host the St. Louis Cardinals on May 28, 2025. First pitch from Oriole Park at Camden Yards is scheduled for 6:35 p.m. EDT; the game will be broadcast on MASN.
The Orioles enter as -112 favorites on the moneyline with the over/under sitting at 7.5.
Find my Cardinals vs Orioles prediction and MLB betting preview below, as well as probable pitchers, betting trends, injury reports and more.
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- Cardinals vs Orioles Pick: Under 8
My Orioles vs. Cardinals best bet is for both teams to go under the total. Make sure to find the best odds by checking our live MLB odds page.
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Cardinals vs Orioles Odds, Spread, Line
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[playercomparison league=”mlb” date=”20250528″ title=”Cardinals vs Orioles Projected Starting Pitchers” awayplayerid=”81393″ awayplayerdisplay=”Miles Mikolas (STL)” homeplayerid=”205994″ homeplayerdisplay=”Cade Povich (BAL)” stattype=”pitching”][/playercomparison]
Cardinals vs Orioles MLB Preview
“Weather Watch Unders” is a system built for bettors who target MLB totals and understand how environmental factors quietly shift run production.
This approach keys in on games with moderate to strong winds, especially those blowing in or cross-field, paired with mild to cool temperatures, a known recipe for stifled fly balls and reduced scoring. When totals open high, but tick down before first pitch, it signals sharp money reacting to these same weather cues.
With home moneyline ranges set to exclude extreme mismatches, the model focuses on fairly priced contests where weather truly has a chance to swing scoring. Layer in the context of regular-season motivation and this strategy captures overlooked market inefficiencies in totals that are inflated by prior offensive output, rather than the conditions on the field.
Overall, this system has a 7% ROI (1531-1234-150), but this season it has generated an impressive 26% ROI (58-30-2).
Cardinals vs Orioles Pick, Best Bets
Pick: Under 8
Cardinals vs Orioles Betting Trends to Watch
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[howtowatch gameid=”255813″ date=”20250528″][/howtowatch]
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[gameforecast league=”mlb” gameid=”255813″ date=”20250528″][/gameforecast]
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