The Cincinnati Reds (60-54) and Chicago Cubs (65-48) will face off in the MLB this afternoon. First pitch from Wrigley Field is scheduled for 2:20 p.m. ET. The game will broadcast live on MARQ.
Chicago is a -135 favorite to win outright on the moneyline, while Cincinnati is +115 to pull off the upset. The over/under is set at 7.5 total runs.
Continue below for my Reds vs Cubs predictions and MLB picks for Wednesday, August 6, as well as probable pitchers, betting trends, injury reports and more.
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Reds vs Cubs Prediction, Picks
- Reds vs Cubs pick: Under 7.5 Runs (-115)
My Cubs vs. Reds best bet is on the under, with the best price currently available at Fanatics. But as always, make sure to find the best odds by checking our live MLB odds page.
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Reds vs Cubs Odds for Wednesday, August 6
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Cincinnati Reds vs Chicago Cubs MLB Preview
This system capitalizes on an overlooked weather edge in MLB totals betting.
It focuses on regular-season games when elevated humidity — ranging from 45 to 95 — intersects with moderate temperatures and neutral wind patterns, which is the forecast entering today’s matchup between the Reds and Cubs.
Despite assumptions that humidity boosts offense, public bettors are fading these conditions, which actually correlate with suppressed scoring in certain environments.
In these spots, the home team has stayed under in recent games, with their five-game over rate sitting below 40, suggesting low offensive rhythm.
The market has subtly corrected as well, with the total dropping from open to close, and the overall percentage of bets on the over remains modest — between 6 and 29.
These indicators combine to identify under-the-radar under spots where public narratives misalign with actual scoring trends.
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Reds vs Cubs Betting Prediction
- Under 7.5 (-115)
Reds vs Cubs Betting Trends
[bettingtrends title=”” gameid=”258714″ date=”20250806″][/bettingtrends]
[howtowatch gameid=”258714″ date=”20250806″][/howtowatch]
[subheader sizedown=”true” text=”Reds vs Cubs Weather” center=”false”][/subheader]
[gameforecast league=”mlb” gameid=”258714″ date=”20250806″][/gameforecast]
[gameinjuries league=”mlb” gameid=”258714″ date=”20250806″ week=”” seasontype=””][/gameinjuries]