The St. Louis Cardinals (54-51) and San Diego Padres (55-49) will face off in the MLB tonight. First pitch from Busch Stadium is scheduled for 7:15 p.m. ET. The game will broadcast live on SDPA.
St. Louis is a -150 favorite to win outright on the moneyline, while San Diego is +125 to pull off the upset. The over/under is set at 9 total runs.
Continue below for my Padres vs Cardinals predictions and MLB picks for Saturday, July 26, as well as probable pitchers, betting trends, injury reports and more.
[quickslipbasic bookname=”DraftKings” booklogo=”https://assets.actionnetwork.com/128508_Primary1.png” image=”https://images.actionnetwork.com/blog/2025/07/IMG_6478.jpg” buttontext=”Place This Bet Instantly!” buttonlink=”https://www.scoresandodds.com/all/parlay?quickslip=1&slipAdd=2faf1db4-01e8-471a-884a-9b2dc13ddf67&ref=10001″][/quickslipbasic]
[subheader sizedown=”false” text=”My Padres vs Cardinals Prediction” center=”true” logo1url=”https://static.sprtactn.co/teamlogos/mlb/100/sd.png” link1=”https://www.actionnetwork.com/mlb/odds/san-diego-padres” link1follow=”true” logo2url=”https://static.sprtactn.co/teamlogos/mlb/100/stl.png” link2=”https://www.actionnetwork.com/mlb/odds/st.-louis-cardinals” link2follow=”true”][/subheader]
- Padres vs Cardinals pick: Cardinals Moneyline (-150)
My Cardinals vs. Padres best bet is on St. Louis moneyline, with the best odds currently available at DraftKings. But as always, make sure to find the best odds by checking our live MLB odds page.
_InlineAdBlock
Padres vs Cardinals Odds
[gamematchup league=”mlb” awaylogo=”https://static.sprtactn.co/teamlogos/mlb/100/sd.png” awayname=”Padres” awayslug=”san-diego-padres” homelogo=”https://static.sprtactn.co/teamlogos/mlb/100/stl.png” homename=”Cardinals” homeslug=”st.-louis-cardinals” date=”Saturday, July 26″ time=”7:15 p.m. ET” network=”SDPA” col1text=”Spread” col2text=”Total” col3text=”Moneyline” col1awaytext=”+1.5″ col1awayline=”-160″ col1hometext=”-1.5″ col1homeline=”+135″ col2awaytext=”9″ col2hometext=”9″ col2awayline=”-115o / -105u” col2homeline=”-115o / -105u” col3awaytext=”+125″ col3hometext=”-150″ col3awayline=”” col3homeline=”” bookname=”DraftKings” bookthumbnaillogo=”https://assets.actionnetwork.com/364880_Draftkings.png” bookreviewslug=”draftkings”][/gamematchup]
[playercomparison league=”mlb” date=”20250726″ title=”Padres vs Cardinals Projected Starting Pitchers” awayplayerid=”190530″ awayplayerdisplay=”Randy Vasquez (SD)” homeplayerid=”87831″ homeplayerdisplay=”Matthew Liberatore (STL)” stattype=”pitching”][/playercomparison]
Padres vs Cardinals Preview, Picks
This system identifies winning teams that are performing steadily but not drawing overwhelming market attention, which appears to be the case for the Cardinals tonight heading into a home matchup against the Padres.
This system targets regular-season teams with at least a breakeven win rate that are coming off a modest but positive result, winning their previous game by between one and seven runs.
Their prior moneyline price indicates they weren’t heavy favorites — just expected to win.
When they return as moderate favorites again, and have a consistent streak of games either home or away, it suggests controlled momentum rather than volatility.
The setup capitalizes on teams that are undervalued by the public due to their lack of flashy blowouts or extreme winning streaks, offering value where confidence exceeds perception.
[betlabsembed systemid=”1479160″ systemname=”Evan Abrams / Bet Labs – Quiet Confidence System” leaguename=”mlb” filters=”%7B%22list%22%3A%5B%22the%20team’s%20win%20percentage%20is%20between%2050%25%20and%20100%25%22%2C%22the%20game%20is%20played%20during%20the%20Regular%20season%22%2C%22the%20team’s%20previous%20game%20margin%20is%20between%201%20and%207%22%2C%22the%20team’s%20moneyline%20in%20their%20previous%20game%20was%20between%20100%20and%20171%22%2C%22the%20closing%20moneyline%20is%20between%20-235%20and%20-125%22%2C%22the%20team%E2%80%99s%20home%2Faway%20streak%20is%20between%202%20and%208%20games%22%5D%7D” amountwon=”$5,816″ record=”329-161-0″ winpct=”67%”][/betlabsembed]
Padres vs Cardinals Best Bet
- Cardinals ML (-150)
Padres vs Cardinals Betting Trends
[bettingtrends title=”” gameid=”258209″ date=”20250726″][/bettingtrends]
[howtowatch gameid=”258209″ date=”20250726″][/howtowatch]
[subheader sizedown=”true” text=”Padres vs Cardinals Weather” center=”false”][/subheader]
[gameforecast league=”mlb” gameid=”258209″ date=”20250726″][/gameforecast]