The St. Louis Cardinals host the New York Yankees on August 17, 2025. First pitch from Busch Stadium is scheduled for 2:15 p.m. EDT; the game will be broadcast on YES.
Find my MLB betting preview and Yankees vs Cardinals prediction below, as well as probable pitchers, betting trends, injury reports and more.
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[subheader sizedown=”false” text=”My Yankees vs Cardinals Prediction” center=”true” logo1url=”https://static.sprtactn.co/teamlogos/mlb/100/nyyd.png” link1=”https://www.actionnetwork.com/mlb/odds/new-york-yankees” link1follow=”true” logo2url=”https://static.sprtactn.co/teamlogos/mlb/100/stl.png” link2=”https://www.actionnetwork.com/mlb/odds/st.-louis-cardinals” link2follow=”true”][/subheader]
- Yankees vs Cardinals picks: Under 9
My Yankees vs Cardinals best bet is on game totals with the best odds currently on Fanatics. Make sure to find the best odds by checking our live MLB odds page.
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Yankees vs Cardinals Odds, Spread, Best Bet
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Yankees vs Cardinals Run Line: Yankees -1.5 (+105); Cardinals +1.5 (-127)
Yankees vs Cardinals Totals: 9 (O +101 / U -123)
Yankees vs Cardinals Moneyline: Yankees -156; Cardinals +128
Yankees vs Cardinals Best Bet: Under 9 Total Runs
Yankees vs Cardinals Projected Starting Pitchers
| RHP Will Warren (NYY) | Stat | RHP Miles Mikolas (STL) |
|---|---|---|
| 7-5 | W-L | 6-9 |
| 2.0 | fWAR (FanGraphs) | 0.5 |
| 4.34 / 4.00 | ERA /xERA | 4.97 / 5.06 |
| 3.68 / 3.60 | FIP / xFIP | 4.78 / 4.66 |
| 1.37 | WHIP | 1.28 |
| 16.2% | K-BB% | 10.8% |
| 44.4% | GB% | 38.5% |
| 99 | Stuff+ | 92 |
| 99 | Location+ | 108 |
Yankees vs Cardinals Prediction, Betting Analysis
When the wind is blowing in at specific stadiums known for wind sensitivity, like Busch Stadium, scoring tends to be suppressed due to reduced ball carry.
Betting the Under in these conditions—regardless of whether it’s the regular season or postseason—has shown consistent profitability both in the short and long term.
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Pick: Under 9
Yankees vs Cardinals Betting Trends
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[howtowatch gameid=”259149″ date=”20250817″][/howtowatch]
[subheader sizedown=”true” text=”Yankees vs Cardinals Weather” center=”false”][/subheader]
[gameforecast league=”mlb” gameid=”259149″ date=”20250817″][/gameforecast]