Two PRO Systems both agree on a moneyline pick Friday when the St. Louis Cardinals and Cleveland Guardians open a three-game series.
Friday’s 7:10 p.m. ET first pitch pits the Cardinals out of the NL on the road against the American League’s Guardians, with both teams holding similar records as they prepare to face off for an interleague set.
St. Louis will send pitcher Sonny Gray to the mound against Cleveland’s Luis Ortiz. Notably, the betting market shows the Cardinals as consensus road favorites at -131, while the Guardians are priced at +108.
Two distinct PRO Systems, cashing 63% and 62% lifetime, recognize subtle edges favoring a moneyline prediction for Friday.
And the pick is in!
Cardinals vs. Guardians MLB Moneyline Pick for 6/27
On Friday, the St. Louis Cardinals moneyline is a match for two of Action PRO baseball models.
The first PRO System at play here is known as the “Road Flip Fave” model, hitting 63% on past picks.
This system zeroes in on regular-season games where a team transitions from a home game to the road and becomes a mild favorite in a non-division matchup. Often, the market overreacts to a team’s recent home performance, inflating confidence that doesn’t fully account for travel fatigue, unfamiliarity, and opponent adjustments. The Cards fall within the recommended moneyline range of -121 to -140 at -131, making them an ideal fit on Friday.
The second valuable PRO System supporting St. Louis is “Road Tilt in the Dead Heat.” This system, nailing 62% of past predictions, identifies games featuring two evenly matched opponents by win percentage when the road team is slightly favored. When the market tilts modestly towards the visitors under these conditions, it indicates subtle market confidence that often escapes broader perception. The Cardinals benefit here as well.
PRO Systems Pick: Cardinals ML
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