Fifteen games are on the Major League Baseball slate on Saturday, May 17, and our betting experts are all over it with three MLB best bets.
Saturday’s MLB picks and predictions include two moneyline bets on road underdogs, plus a spread pick for Angels vs Dodgers, which features the season debut of Clayton Kershaw.
Find our MLB best bets and parlay for Saturday below.
[quickslipbasic bookname=”Fanatics” booklogo=”https://assets.actionnetwork.com/573837_FanaticsSportsbook20ALT.png” image=”https://images.actionnetwork.com/blog/2025/05/IMG_1032.jpg” buttontext=”+802 MLB Best Bets Parlay on Fanatics” buttonlink=”https://www.scoresandodds.com/all/parlay?quickslip=1&onelink=/5kut/q63tyi7j?sharedBy=QS_0105&ref=10001″][/quickslipbasic]
MLB Best Bets, Picks, Predictions Today — 5/17
| Game | Time (ET) | Pick |
|---|---|---|
| [teammatchup link=”#2″ firstfullname=”Washington Nationals” firstlogo=”https://images.actionnetwork.com/blog/2023/08/2023-mlb-logo-washington-nationals.png” secondfullname=”Baltimore Orioles” secondlogo=”https://static.sprtactn.co/teamlogos/mlb/100/bal.png”][/teammatchup] | 4:05 p.m. | |
| [teammatchup link=”#3″ firstfullname=”Los Angeles Angels” firstlogo=”https://static.sprtactn.co/teamlogos/mlb/100/laa.png” secondfullname=”Los Angeles Dodgers” secondlogo=”https://images.actionnetwork.com/blog/2023/08/2023-mlb-logo-los-angeles-dodgers.png”][/teammatchup] | 9:10 p.m. | |
| [teammatchup link=”#1″ firstfullname=”New York Mets” firstlogo=”https://images.actionnetwork.com/blog/2023/08/2023-mlb-logo-new-york-mets.png” secondfullname=”New York Yankees” secondlogo=”https://static.sprtactn.co/teamlogos/mlb/100/nyyd.png”][/teammatchup] | 1:05 p.m. | |
|
Specific betting recommendations come from the sportsbook offering preferred odds as of writing. Always shop for the best price using our MLB Odds page, which automatically surfaces the best lines for every game.
|
||
[relatedarticle articleimageurl=”https://images.actionnetwork.com/blog/2025/05/Ohtani-LAD-5172025.jpg” linktext=”Angels vs Dodgers Predictions, Parlay, Picks, Odds for Saturday, May 17″ link=”https://www.actionnetwork.com/mlb/los-angeles-angels-vs-los-angeles-dodgers-predictions-parlay-picks-odds-saturday-may-17-qs”][/relatedarticle]
[anchor name=”1″][/anchor]
[subheader sizedown=”false” text=”Mets vs Yankees Best Bet: Back Road Underdog”][/subheader]
[gameheader haspick=”true” picktext=”Mets Moneyline (+110)” league=”mlb” awaylogo=”https://images.actionnetwork.com/blog/2023/08/2023-mlb-logo-new-york-mets.png” awayname=”New York Mets” awayslug=”new-york-mets” homelogo=”https://static.sprtactn.co/teamlogos/mlb/100/nyyd.png” homename=”New York Yankees” homeslug=”new-york-yankees” date=”Saturday, May 17″ time=”1:05 p.m. ET” network=”MLB.TV” bookname=”Caesars Sportsbook” bookprimarylogo=”https://assets.actionnetwork.com/256064_caesars_800x200.png” bookreviewslug=”caesars-sportsbook”][/gameheader]
By Bet Labs
In interleague matchups early in a series, road underdogs often hold unseen advantages. In this case, that’s the Mets as road ‘dogs on Saturday against the Yankees.
These games introduce travel and scouting uncertainty, and early games feature lineups and matchups unfamiliar to bettors and models.
Public perception tends to lean too heavily on home-field advantage. Interleague games introduce more unpredictability due to differences in lineup construction and unfamiliar opposing pitchers.
When combined with road dog pricing, it creates exploitable inefficiencies in early matchups.
[betlabsembed systemid=”1474957″ systemname=”Evan Abrams – Road Dogs Interleague, Early Series (YEAR)” leaguename=”mlb” filters=”%7B%22list%22%3A%5B%22the%20team%20is%20the%20Dog%22%2C%22the%20team%20is%20the%20Visitor%20team%22%2C%22the%20game%20is%20a%20Non-Conference%20game%22%2C%22the%20game%20is%20played%20during%20the%20Regular%20season%22%2C%22the%20series%20game%20%23%20is%20between%201%20and%202%22%2C%22the%20game%20was%20played%20during%20the%202025%20or%202024%20or%202023%20or%202022%20or%202021%20or%202020%20or%202019%20or%202018%20or%202017%20season%22%5D%7D” amountwon=”$7,928″ record=”699-890-0″ winpct=”44%”][/betlabsembed]
Pick: Mets Moneyline (+110)
_InlineAdBlock
| [teammatchup link=”#1″ shadow=”true” firstfullname=”New York Mets” firstlogo=”https://images.actionnetwork.com/blog/2023/08/2023-mlb-logo-new-york-mets.png” secondfullname=”New York Yankees” secondlogo=”https://static.sprtactn.co/teamlogos/mlb/100/nyyd.png”][/teammatchup] | [teammatchup link=”#2″ shadow=”true” firstfullname=”Washington Nationals” firstlogo=”https://images.actionnetwork.com/blog/2023/08/2023-mlb-logo-washington-nationals.png” secondfullname=”Baltimore Orioles” secondlogo=”https://static.sprtactn.co/teamlogos/mlb/100/bal.png”][/teammatchup] | [teammatchup link=”#3″ shadow=”true” firstfullname=”Los Angeles Angels” firstlogo=”https://static.sprtactn.co/teamlogos/mlb/100/laa.png” secondfullname=”Los Angeles Dodgers” secondlogo=”https://images.actionnetwork.com/blog/2023/08/2023-mlb-logo-los-angeles-dodgers.png”][/teammatchup] |
[anchor name=”2″][/anchor]
[subheader sizedown=”false” text=”Nationals vs Orioles Best Bet: Value on Nats Moneyline”][/subheader]
[gameheader haspick=”true” picktext=”Nationals Moneyline (+130)” league=”mlb” awaylogo=”https://images.actionnetwork.com/blog/2023/08/2023-mlb-logo-washington-nationals.png” awayname=”Washington Nationals” awayslug=”washington-nationals” homelogo=”https://static.sprtactn.co/teamlogos/mlb/100/bal.png” homename=”Baltimore Orioles” homeslug=”baltimore-orioles” date=”Saturday, May 17″ time=”4:05 p.m. ET” network=”MLB.TV” bookname=”bet365″ bookprimarylogo=”https://assets.actionnetwork.com/859377_Bet365@1x.png” bookreviewslug=”bet365″][/gameheader]
By Bet Labs
Sticking with the theme from the Mets-Yankees game, road underdogs playing interleague (non-conference) games have historically been undervalued by oddsmakers.
Since 2016, despite winning only 43.3% of these games, these teams have generated a consistent positive ROI of 4.6%. This trend has proven reliable across five consecutive seasons, indicating market inefficiencies in how these specific matchups are priced — likely due to lack of familiarity between leagues and public overconfidence in home and favorite teams.
In interleague play, road underdogs have shown themselves to be profitable on the moneyline recently. They have only a 43.3% win percentage, but those teams have turned a 4.6% ROI for bettors since 2016 and have been profitable in five consecutive seasons.
It’s also hard to not like the Nationals at plus money in this spot against Orioles starter Kyle Gibson, who enters Saturday with a woeful 13.11 ERA over three starts spanning 11 2/3 innings. The Orioles have lost each of his starts.
[betlabsembed systemid=”1474970″ systemname=”Evan Abrams – Road Dogs Interleague (YEAR)” leaguename=”mlb” filters=”%7B%22list%22%3A%5B%22the%20game%20is%20played%20during%20the%20Regular%20season%22%2C%22the%20game%20is%20a%20Non-Conference%20game%22%2C%22the%20team%20is%20the%20Visitor%20team%22%2C%22the%20team%20is%20the%20Dog%22%2C%22the%20game%20was%20played%20during%20the%202025%20or%202024%20or%202023%20or%202022%20or%202021%20or%202020%20or%202019%20or%202018%20or%202017%20or%202016%20season%22%5D%7D” amountwon=”$5,141″ record=”1015-1351-0″ winpct=”43%”][/betlabsembed]
Pick: Nationals Moneyline (+130)
| [teammatchup link=”#1″ shadow=”true” firstfullname=”New York Mets” firstlogo=”https://images.actionnetwork.com/blog/2023/08/2023-mlb-logo-new-york-mets.png” secondfullname=”New York Yankees” secondlogo=”https://static.sprtactn.co/teamlogos/mlb/100/nyyd.png”][/teammatchup] | [teammatchup link=”#2″ shadow=”true” firstfullname=”Washington Nationals” firstlogo=”https://images.actionnetwork.com/blog/2023/08/2023-mlb-logo-washington-nationals.png” secondfullname=”Baltimore Orioles” secondlogo=”https://static.sprtactn.co/teamlogos/mlb/100/bal.png”][/teammatchup] | [teammatchup link=”#3″ shadow=”true” firstfullname=”Los Angeles Angels” firstlogo=”https://static.sprtactn.co/teamlogos/mlb/100/laa.png” secondfullname=”Los Angeles Dodgers” secondlogo=”https://images.actionnetwork.com/blog/2023/08/2023-mlb-logo-los-angeles-dodgers.png”][/teammatchup] |
[anchor name=”3″][/anchor]
[subheader sizedown=”false” text=”Angels vs Dodgers Spread Prediction”][/subheader]
[gameheader haspick=”true” picktext=”Dodgers Run Line -1.5 (-122)” league=”mlb” awaylogo=”https://static.sprtactn.co/teamlogos/mlb/100/laa.png” awayname=”Los Angeles Angels” awayslug=”los-angeles-angels” homelogo=”https://images.actionnetwork.com/blog/2023/08/2023-mlb-logo-los-angeles-dodgers.png” homename=”Los Angeles Dodgers” homeslug=”los-angeles-dodgers” date=”Saturday, May 17″ time=”9:10 p.m. ET” network=”MLB Network” bookname=”DraftKings ” bookprimarylogo=”https://assets.actionnetwork.com/477013_DraftKings@1x.png” bookreviewslug=”draftkings”][/gameheader]
By Nick Galaida
Since Mike Trout last played on April 30, the Angels have a league-worst 6 wRC+ against left-handed pitching. Bad news, as they are facing on the best ever on Saturday in Clayton Kershaw, who is making his season debut.
They have walked in only 3.7% of their plate appearances while striking out at a ghastly 35.2% rate in that span, with only two extra-base hits in 54 plate appearances. Meanwhile, the Dodgers‘ offense leads all of baseball in that span with a 219 wRC+ against southpaws.
Kershaw’s fastball infrequently gets above 90 mph these days, but he’s still likely capable of keeping this Angels offense off-balance this evening.
The Dodgers also have a fully rested arm bullpen behind him.
If the Dodgers’ bats come to play, this could be a rout.
Pick: Dodgers Run Line -1.5 (-122)
| [teammatchup link=”#1″ shadow=”true” firstfullname=”New York Mets” firstlogo=”https://images.actionnetwork.com/blog/2023/08/2023-mlb-logo-new-york-mets.png” secondfullname=”New York Yankees” secondlogo=”https://static.sprtactn.co/teamlogos/mlb/100/nyyd.png”][/teammatchup] | [teammatchup link=”#2″ shadow=”true” firstfullname=”Washington Nationals” firstlogo=”https://images.actionnetwork.com/blog/2023/08/2023-mlb-logo-washington-nationals.png” secondfullname=”Baltimore Orioles” secondlogo=”https://static.sprtactn.co/teamlogos/mlb/100/bal.png”][/teammatchup] | [teammatchup link=”#3″ shadow=”true” firstfullname=”Los Angeles Angels” firstlogo=”https://static.sprtactn.co/teamlogos/mlb/100/laa.png” secondfullname=”Los Angeles Dodgers” secondlogo=”https://images.actionnetwork.com/blog/2023/08/2023-mlb-logo-los-angeles-dodgers.png”][/teammatchup] |