The St. Louis Cardinals host the Kansas City Royals on Thursday, June 5, 2025. First pitch for Game 1 of the doubleheader from Busch Stadium is scheduled for 1:45 p.m. ET; the game will be broadcast on FanDuel Sports Kansas City/Midwest.
Find my Royals vs Cardinals prediction for Game 1 on Thursday below.
Editor’s Note: This game was originally scheduled to be played on Wednesday but was postponed due to inclement weather. Noah Cameron and Miles Mikolas remain the probable starting pitchers for the Royals and Cardinals, respectively.
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- Royals vs Cardinals Picks: Royals Moneyline +108
My Royals vs Cardinals best bet is on Royals moneyline. Make sure to find the best odds by checking our live MLB odds page.
Royals vs Cardinals Odds
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Royals vs Cardinals Projected Starting Pitchers
| Noah Cameron (KC) | Stat | Miles Mikolas (STL) |
|---|---|---|
| 2-1 | W-L | 4-2 |
| 0.4 | fWAR (FanGraphs) | 1.0 |
| 1.05 / 3.14 | ERA /xERA | 3.90 / 4.33 |
| 3.77 / 4.50 | FIP / xFIP | 3.52 / 4.90 |
| 0.82 | WHIP | 1.25 |
| 8.2 | K-BB% | 7.7 |
| 38.9 | GB% | 36.7 |
| 93 | Stuff+ | 88 |
| 102 | Location+ | 107 |
Cardinals vs Royals Game 1 Prediction, Preview
Evan Abrams’ system called “Road Dogs Interleague” is lighting up for this Royals vs. Cardinals matchup on Wednesday at Busch Stadium.
The second game of this three-game set comes after the Royals scored 10 runs on the Cardinals on Tuesday evening, winning 10-7.
This system is projecting yet another victory for Kansas City on Wednesday.
The good news is this system is +$6259 with a 2.6% ROI since its inception, making this a solid target for your MLB betting card.
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Royals vs Cardinals Game 1 Pick, Best Bet: Royals ML +108
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Moneyline
I’m taking the underdog on the moneyline.
Run Line (Spread)
I don’t have a play on the run line.
Over/Under
I don’t have a play on the total.
Royals vs Cardinals Betting Trends
[bettingtrends title=”” gameid=”257621″ date=”20250605″][/bettingtrends]
[subheader sizedown=”true” text=”Royals vs Cardinals Weather” center=”false”][/subheader]
[gameforecast league=”mlb” gameid=”257621″ date=”20250605″][/gameforecast]