astros-vs-athletics-prediction-pick-odds-june-16 Pictured: Jose Altuve

Astros vs Athletics Prediction, Pick, Odds for Monday

The Athletics host the Houston Astros on June 16, 2025. First pitch from Sutter Health Park is scheduled for 10:05 p.m. EDT; the game will be broadcast on SCHN.

Find my MLB betting preview and Astros vs Athletics prediction below, as well as probable pitchers, betting trends, injury reports and more.

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  • Astros vs Athletics picks: Astros Moneyline

My Astros vs Athletics best bet is the Astros moneyline. Make sure to find the best odds by checking our live MLB odds page.

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Astros vs Athletics Odds

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[playercomparison league=”mlb” date=”20250616″ title=”Astros vs Athletics Projected Starting Pitchers” awayplayerid=”3402″ awayplayerdisplay=”Lance McCullers (HOU)” homeplayerid=”190566″ homeplayerdisplay=”Mitch Spence (ATH)” stattype=”pitching”][/playercomparison]

Astros vs Athletics Prediction, Betting Analysis

This system targets road favorites whose starting pitchers have both a high ERA (4.56+) and WHIP (1.36 to 10.45), suggesting below-average effectiveness. Despite the performance of the starter, these teams are still priced between -225 and -150, indicating public or market confidence that may not necessarily be justified by the pitching metrics.

However, just because the pitching metrics don’t scream dominance, that doesn’t mean there isn’t value. After all, there’s a reason these teams are priced as road favorites.

This system also focuses on regular-season games from 2020-2024, isolating proven inefficiencies in recent betting markets. In that time frame, this system has generated a 12% ROI, going 108-44-0 (71%). Looking at just this season, the ROI is 13% (10-4-0, 71%).

Pick: Astros Moneyline


Moneyline

As mentioned above, we’re backing the Astros on the moneyline.


Run Line (Spread)

We’re going to pass on the Astros vs. Athletics run line as the current odds don’t show any value.


Over/Under

We have no system play on the Astros vs. Athletics over/under.


Astros vs Athletics Betting Trends

[bettingtrends title=”” gameid=”256504″ date=”20250616″][/bettingtrends]


[howtowatch gameid=”256504″ date=”20250616″][/howtowatch]

Astros vs Athletics starts at 10:05 p.m. EDT on Monday, live from Sutter Health Park. The game will be broadcast on SCHN.


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