The Arizona Diamondbacks host the Houston Astros on Wednesday, July 23. First pitch from Chase Field in Phoenix, Arizona, is scheduled for 3:40 p.m. ET; the game will be broadcast on MLB Network.
The Diamondbacks enter as -135 favorites on the moneyline, while the Astros come in at +115 to pull off the upset. The over/under, meanwhile, sits at 8.5 total runs.
Find my Astros vs Diamondbacks prediction and MLB betting preview below, as well as probable pitchers, betting trends, injury reports and more for their game on Wednesday, July 23.
[quickslipbasic bookname=”DraftKings” booklogo=”https://assets.actionnetwork.com/128508_Primary1.png” image=”https://images.actionnetwork.com/blog/2025/07/Screenshot-2025-07-23-at-8.15.59%E2%80%AFAM.png” buttontext=”Tail This Pick Instantly!” buttonlink=”https://www.scoresandodds.com/all/parlay?quickslip=1&slipAdd=0be245ef-ad53-4a19-b6a3-bcee7a2f6f75&ref=10001″][/quickslipbasic]
[subheader sizedown=”false” text=”My Astros vs Diamondbacks Prediction” center=”true” logo1url=”https://static.sprtactn.co/teamlogos/mlb/100/hou.png” link1=”https://www.actionnetwork.com/mlb/odds/houston-astros” link1follow=”true” logo2url=”https://assets.actionnetwork.com/976480_dbacks.png” link2=”https://www.actionnetwork.com/mlb/odds/arizona-diamondbacks” link2follow=”true”][/subheader]
- Astros vs. Diamondbacks Pick: Under 8.5
My Diamondbacks vs. Astros best bet is for both teams to go under the total in this game. Make sure to find the best odds by checking our live MLB odds page.
_InlineAdBlock
Astros vs Diamondbacks Odds, Spread, Lines
[gamematchup league=”mlb” awaylogo=”https://static.sprtactn.co/teamlogos/mlb/100/hou.png” awayname=”Astros” awayslug=”houston-astros” homelogo=”https://assets.actionnetwork.com/976480_dbacks.png” homename=”Diamondbacks” homeslug=”arizona-diamondbacks” date=”Wednesday, July 23″ time=”3:40 p.m. ET” network=”MLB Network” col1text=”Run Line” col2text=”Total” col3text=”Moneyline” col1awaytext=”+1.5″ col1awayline=”-190″ col1hometext=”-1.5″ col1homeline=”+155″ col2awaytext=”8.5″ col2hometext=”8.5″ col2awayline=”+100o / -120u” col2homeline=”+100o / -120u” col3awaytext=”+115″ col3hometext=”-135″ col3awayline=”” col3homeline=”” bookname=”BetMGM” bookthumbnaillogo=”https://assets.actionnetwork.com/902516_MGM2.png” bookreviewslug=”betmgm”][/gamematchup]
Astros vs Diamondbacks Pick, Best Bets
This system targets unders in interleague games between winning clubs in which the market sets a modest total (7-10).
The setup leverages solid teams (49-100% win rate) facing unfamiliar lineups and pitchers in later-season matchups (game 22+). It also looks for spots in which the home team is favored (moneyline -260 to -110).
The result? Profitable unders in tight, more disciplined matchups between quality teams with limited recent exposure to each other.
Overall, this system has generated an 8% ROI as it has cashed 56% (676-529-66) of its lifetime picks. This season, it’s cashing picks at a 53% clip, going 50-45-2.
[betlabsembed systemid=”1478936″ systemname=”Evan Abrams / Bet Labs – Interleague Under Edge” leaguename=”mlb” filters=”%7B%22list%22%3A%5B%22the%20home%20money%20is%20between%20-260%20and%20-110%22%2C%22the%20closing%20total%20is%20between%207%20and%2010%22%2C%22the%20home%20team’s%20game%20number%20is%20between%2022%20and%20161%22%2C%22the%20game%20is%20a%20Non-Conference%20game%22%2C%22the%20home%20team’s%20win%20percentage%20is%20between%2049%25%20and%20100%25%22%2C%22the%20visitor%20team’s%20win%20percentage%20is%20between%2049%25%20and%20100%25%22%2C%22betting%20on%20the%20Under%22%5D%7D” amountwon=”$10,282″ record=”676-529-66″ winpct=”56%”][/betlabsembed]
Pick: Under 8.5
Astros vs Diamondbacks Moneyline
We’re going to pass on the Astros vs. Diamondbacks moneyline.
Astros vs Diamondbacks Run Line (Spread)
We don’t have a Astros vs. Diamondbacks run line pick.
Astros vs Diamondbacks Over/Under
As detailed above, we’re betting the Astros vs. Diamondbacks over/under and are projecting the game to finish with under 8.5 total runs.
Astros vs Diamondbacks Betting Trends to Know
[bettingtrends title=”” gameid=”258090″ date=”20250723″][/bettingtrends]
[procard imageurl=”https://assets.actionnetwork.com/736824_ActionPRO_promo_1500x844.jpg” cta=”Premium picks, tools & analysis” firstupsell=”Track & follow smart money” secondupsell=”Biggest player prop edges” thirdupsell=”Real-time expert pick alerts” buttontext=”SAVE 66% NOW!” buttonurl=”/pricing”][/procard]