The Washington Nationals (16-19) host the Cleveland Guardians (20-14) on May 6, 2025. First pitch from Nationals Park is scheduled for 3:35 p.m. ET; the game will be broadcast on MASN2.
Find our Guardians vs Nationals prediction and MLB player prop picks below.
[quickslipbasic bookname=”DraftKings” booklogo=”https://assets.actionnetwork.com/128508_Primary1.png” image=”https://images.actionnetwork.com/blog/2025/05/Screenshot-2025-05-06-at-10.57.38-AM.png” buttontext=”Tail This MLB Prop!” buttonlink=”https://switchboard.actionnetwork.com/v2/deeplink?deeplinkId[0]=ML1540930224&context=qs-articles”][/quickslipbasic]
[subheader sizedown=”false” text=”Guardians vs Nationals Prediction, Game 1 Pick” center=”true” logo1url=”https://assets.actionnetwork.com/91388_guardians20241.png” link1=”https://www.actionnetwork.com/mlb/odds/cleveland-guardians” link1follow=”true” logo2url=”https://static.sprtactn.co/teamlogos/mlb/100/wsh.png” link2=”https://www.actionnetwork.com/mlb/odds/washington-nationals” link2follow=”true”][/subheader]
- Guardians vs Nationals pick: Luis L. Ortiz Over 15.5 Pitching Outs
My Guardians vs Nationals best bet is on Luis L. Ortiz’s pitching outs prop. Check our live MLB odds page to find the best odds.
Guardians vs Nationals Odds
[gamematchup league=”mlb” awaylogo=”https://assets.actionnetwork.com/91388_guardians20241.png” awayname=”Guardians” awayslug=”cleveland-guardians” homelogo=”https://static.sprtactn.co/teamlogos/mlb/100/wsh.png” homename=”Nationals” homeslug=”washington-nationals” date=”May 6, 2025″ time=”3:35 p.m. EDT” network=”MASN2″ col1text=”Spread” col2text=”Over/Under” col3text=”Moneyline” col1awaytext=”-1.5″ col1awayline=”+140″ col1hometext=”+1.5″ col1homeline=”-170″ col2awaytext=”9.5″ col2hometext=”9.5″ col2awayline=”+100o / -120u” col2homeline=”+100o / -120u” col3awaytext=”-120″ col3hometext=”+100″ col3awayline=”” col3homeline=”” bookname=”BetMGM” bookthumbnaillogo=”https://assets.actionnetwork.com/902516_MGM2.png” bookreviewslug=”betmgm”][/gamematchup]
_InlineAdBlock
Guardians vs Nationals Projected Starting Pitchers
| RHP Luis L. Ortiz (CLE) | Stat | RHP Jake Irvin (WAS) |
|---|---|---|
| 2-3 | W-L | 2-1 |
| 0.4 | fWAR (FanGraphs) | 0.2 |
| 4.78 / 4.52 | ERA /xERA | 4.01 / 5.09 |
| 3.94 / 3.82 | FIP / xFIP | 4.80 / 4.02 |
| 1.41 | WHIP | 1.13 |
| 14.3% | K-BB% | 12.7% |
| 47.7% | GB% | 41.7% |
| 98 | Stuff+ | 95 |
| 94 | Location+ | 107 |
Nick Galaida’s Guardians vs Nationals Preview, Prediction
[subheader sizedown=”true” center=”false” text=”Cleveland Guardians Player Prop: Tremendous Value” logo1url=”https://assets.actionnetwork.com/91388_guardians20241.png” link1=”https://www.actionnetwork.com/mlb/odds/cleveland-guardians” link1follow=”false”][/subheader]
Luis L. Ortiz is far from MLB’s most efficient pitcher.
Still, Guardians manager Steven Vogt will likely lean on him as much as possible in Game 1 of Tuesday’s doubleheader against the Guardians, especially at the beginning of a new week.
Ortiz has thrown as many as 104 pitches in a start this season, and he has a track record of benign pulled in the middle of an inning. I wouldn’t be surprised to see him come out for the sixth inning to face only one or two batters.
We’re getting good value on this prop, given the situation and the fact that Washington has been only slightly more aggressive than the average MLB lineup in recent weeks.
Pick: Luis L. Ortiz Over 15.5 Pitching Outs
Guardians vs Nationals Betting Trends
[bettingtrends title=”” gameid=”253434″ date=”20250506″][/bettingtrends]
[subheader sizedown=”true” text=”Guardians vs Nationals Weather” center=”false”][/subheader]
[gameforecast league=”mlb” gameid=”253434″ date=”20250506″][/gameforecast]