The San Diego Padres host the Cleveland Guardians on March 31, 2025. First pitch from Petco Park is scheduled for 9:40 p.m. ET. The game will be broadcast on MLB.TV.
The Padres enter Monday’s game as a -135 favorite on the moneyline with the over/under sitting at 8 runs.
Find my MLB betting preview and Guardians vs Padres prediction below, as well as probable pitchers, betting trends, injury reports and more.
[quickslipbasic bookname=”Fanatics” booklogo=”https://assets.actionnetwork.com/573837_FanaticsSportsbook20ALT.png” image=”https://images.actionnetwork.com/blog/2025/03/IMG_4545.jpg” buttontext=”Click to Instantly Add the Under to Bet Slip!” buttonlink=”https://www.scoresandodds.com/all/parlay?quickslip=1&onelink=/5kut/t0iepefv?sharedBy=QS_0105&ref=10001″][/quickslipbasic]
[subheader sizedown=”false” text=”Guardians vs Padres Prediction” center=”true” logo1url=”https://assets.actionnetwork.com/91388_guardians20241.png” link1=”https://www.actionnetwork.com/mlb/odds/cleveland-guardians” link1follow=”true” logo2url=”https://static.sprtactn.co/teamlogos/mlb/100/sd.png” link2=”https://www.actionnetwork.com/mlb/odds/san-diego-padres” link2follow=”true”][/subheader]
- Guardians vs Padres picks: Under 8
My Guardians vs Padres best bet is for both teams to go under the total. Make sure to find the best odds by checking our live MLB odds page.
_InlineAdBlock
Guardians vs Padres Odds
[gamematchup league=”mlb” awaylogo=”https://assets.actionnetwork.com/91388_guardians20241.png” awayname=”Guardians” awayslug=”cleveland-guardians” homelogo=”https://static.sprtactn.co/teamlogos/mlb/100/sd.png” homename=”Padres” homeslug=”san-diego-padres” date=”Monday, March 31″ time=”9:40 p.m. ET” network=”MLB.TV” col1text=”Spread” col2text=”Total” col3text=”Moneyline” col1awaytext=”+1.5″ col1awayline=”-185″ col1hometext=”-1.5″ col1homeline=”+154″ col2awaytext=”8″ col2hometext=”8″ col2awayline=”-118o / -102u” col2homeline=”-118o / -102u” col3awaytext=”+114″ col3hometext=”-135″ col3awayline=”” col3homeline=”” bookname=”DraftKings” bookthumbnaillogo=”https://assets.actionnetwork.com/364880_Draftkings.png” bookreviewslug=”draftkings”][/gamematchup]
Guardians vs Padres Projected Starting Pitchers
- RHP Luis L. Ortiz (CLE) vs. LHP Kyle Hart (SD)
Guardians vs Padres Pick, Betting Analysis
Action PRO insights align on the Guardians vs. Padres to go under the total Monday night at Petco Park.
Luis Ortiz and Kyle Hart get the respective starts for the Guardians and Padres to try and get their teams in the win column; however, it’s the total runs that bettors can exploit in this one.
Monday’s interleague over/under was pinged by Action Network betting models, which submitted a fair total of about 7.29 combined runs. It’s one of the best bets for over/under predictions at the time of writing.
Furthermore, a system labeled “Contrarian Unders for Winning Teams,” which has cashed at a profitable rate over its lifetime, shows that competitive teams facing off historically result in lower-scoring games.
Plus, Petco Park serves as one of the most pitcher-friendly parks in baseball. Last year, it was the third-worst stadium for runs created.
Premium resources from our dashboard foresee a lower-scoring game than the market anticipates in the series opener.
Guardians vs Padres Betting Trends
[bettingtrends title=”” gameid=”251383″ date=”20250331″][/bettingtrends]
[howtowatch gameid=”251383″ date=”20250331″][/howtowatch]
Guardians vs Padres starts at 9:40 p.m. ET on Monday, live from PETCO Park. The game will be broadcast on SDPA and MLB.TV.
[subheader sizedown=”true” text=”Guardians vs Padres Weather” center=”false”][/subheader]
[gameforecast league=”mlb” gameid=”251383″ date=”20250331″][/gameforecast]
[procard imageurl=”https://assets.actionnetwork.com/527348_ProWeekly1500x8441.jpg” cta=”7 Days of PRO Betting Tools” firstupsell=”Track sharp CBB & MLB money” secondupsell=”Player prop & home run projections” thirdupsell=”PRO systems, premium articles & more!” buttontext=”TRY PRO NOW” buttonurl=”/pricing”][/procard]