The Cincinnati Reds host the Cleveland Guardians on May 16, 2025. First pitch from Great American Ball Park is scheduled for 6:40 p.m. ET; the game will be broadcast on CLEG and MLB.TV.
The Guardians enter as -120 favorites on the moneyline with the over/under sitting at 9. I have two players I’m eyeing for home run bets in this in-state showdown.
Find my Guardians vs Reds prediction and MLB betting preview below, as well as probable pitchers, betting trends, injury reports and more.
Note: While parlaying these picks isn’t our official recommendation, we’ve put together an easy way to do so below.
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- Guardians vs Reds Pick: Kyle Manzardo Over 0.5 HRs (+340) · Jose Ramirez Over 0.5 HRs (+340)
My Reds vs. Guardians best bet is on Kyle Manzardo and Jose Ramirez to hit home runs. Make sure to find the best odds by checking our live MLB odds page.
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Guardians vs Reds Odds
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Guardians vs Reds Projected Starting Pitchers
[playercomparison league=”mlb” date=”20250516″ title=”” awayplayerid=”189282″ awayplayerdisplay=”Tanner Bibee (CLE)” homeplayerid=”87825″ homeplayerdisplay=”Brady Singer (CIN)” stattype=”pitching”][/playercomparison]
Guardians vs Reds MLB Betting Preview
[subheader sizedown=”true” center=”false” text=”Guardians Home Run Pick: Kyle Manzardo (+340)” logo1url=”https://assets.actionnetwork.com/91388_guardians20241.png” link1=”https://www.actionnetwork.com/mlb/odds/cleveland-guardians” link1follow=“false”][/subheader]
The weather may be an issue today in Cincy, but I’m risking it considering the spot Manzardo is in.
Brady Singer isn’t a bad pitcher, but he’s struggled against lefty power hitters in his career, allowing a high 1.32 HR/9. Great American Ball Park is the best in the league for lefty power, and temperatures and humidity should be high in Cincy.
I have the true odds here around +275, making this a great bet.
[subheader sizedown=”true” center=”false” text=”Guardians Home Run Pick: Jose Ramirez (+340)” logo1url=”https://assets.actionnetwork.com/91388_guardians20241.png” link1=”https://www.actionnetwork.com/mlb/odds/cleveland-guardians” link1follow=”false”][/subheader]
Everything I said about Kyle Manzardo is the same for J-Ram. The spot is too good to pass up, even with the potential weather issues.
Once again, the ballpark is the best in the league for lefty power, and the matchup is good with Singer’s struggles against left-handed power bats.
I have the true odds here around +275, making this a great bet.
Pick: Kyle Manzardo Over 0.5 HRs (+340) · Jose Ramirez Over 0.5 HRs (+340)
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Guardians vs Reds Betting Trends
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[subheader sizedown=”true” text=”Guardians vs Reds Weather” center=”false”][/subheader]
[gameforecast league=”mlb” gameid=”253787″ date=”20250516″][/gameforecast]
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