The Detroit Tigers host the Arizona Diamondbacks on July 30, 2025. First pitch from Comerica Park is scheduled for 1:10 p.m. ET; the game will be broadcast on MLB Network.
The Tigers are -143 moneyline favorites for this matchup against the Diamondbacks (+114). Detroit (-1.5) is the favorite on the run line. The total for the matchup is set at 8.5 runs.
Find my MLB betting preview and Diamondbacks vs Tigers prediction below, as well as probable pitchers, betting trends, injury reports and more.
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- Diamondbacks vs Tigers pick: Diamondbacks ML +114
My Diamondbacks vs Tigers best bet is on the Diamondbacks moneyline. Make sure to find the best odds by checking our live MLB odds page.
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Diamondbacks vs Tigers Odds & Game Information
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Diamondbacks vs Tigers Betting Insights
It’s no surprise that the Tigers beat up on the Diamondbacks in the first two games of this three-game set, outscoring Arizona by 14 runs across those two outings.
Detroit has one of the best records in baseball (63-46) and enters this outing as the top dogs in the AL Central with a three-game winning streak to protect.
Meanwhile, Arizona is sitting in fourth place in a competitive NL West division. It’s six games under .500 (51-57) entering Wednesday’s affair thanks to a four-game losing streak and a record of 3-7 in its last 10 matchups.
So, why are we backing Arizona in this spot? Well, the expectation is it won’t get swept, especially based on Evan Abrams’ “Road Dogs Interleague” system that currently has a 2.3% ROI since it’s inception in 2016.
Road underdogs often hold unseen advantages, including matchups unfamiliar to bettors and models. The public perception tends to lean too heavily on home-field advantage, which isn’t as strong in baseball.
Interleague games introduce more unpredictability due to differences in lineup construction and unfamiliar opposing pitchers.
When combined with road ‘dog pricing, it creates exploitable inefficiencies in early matchups.
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Thus, there’s great value on the Diamondbacks to avoid the sweep at plus money.
Pick: Diamondbacks ML +114
Moneyline
The play for this game is on the Arizona Diamondbacks on the moneyline as a road underdog.
Run Line (Spread)
There’s no play on the run line, but the expectation is for Arizona to win straight up.
Over/Under
There’s no play on the total, either.
Diamondbacks vs Tigers Betting Trends
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[howtowatch gameid=”258349″ date=”20250730″][/howtowatch]
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