The Houston Astros (60-46) and Washington Nationals (43-62) will face off in the MLB tonight. First pitch from Daikin Park is scheduled for 8:10 p.m. ET. The game will broadcast live on MASN2.
Houston is a -265 favorite to win outright on the moneyline, while Washington is +210 to pull off the upset. The over/under is set at 7.5 total runs.
Continue below for my Nationals vs Astros predictions and MLB picks for Monday, July 28, as well as probable pitchers, betting trends, injury reports and more.
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- Nationals vs Astros pick: Nationals Moneyline (+210)
My Nationals vs Astros best bet is on Washington moneyline, with the best line currently available at DraftKings. But as always, make sure to find the best odds by checking our live MLB odds page.
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Nationals vs Astros Odds
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Nationals vs Astros Preview, Picks
In interleague matchups early in a series, road underdogs often hold unseen advantages, which may be the case in tonight’s matchup between the Nationals and Astros.
These games introduce travel and scouting uncertainty, and early games feature lineups and matchups unfamiliar to bettors and models.
Public perception tends to lean too heavily on home-field advantage.
Interleague games introduce more unpredictability due to differences in lineup construction and unfamiliar opposing pitchers.
When combined with road dog pricing, it creates exploitable inefficiencies in early matchups.
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Nationals vs Astros Best Bet
- Nationals ML (+210)
Nationals vs Astros Betting Trends
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[howtowatch gameid=”258277″ date=”20250728″][/howtowatch]
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