Astros vs Mariners Prediction, Odds, Time: Sunday MLB Picks

The Seattle Mariners host the Houston Astros on Sunday, July 20, 2025. First pitch from T-Mobile Park is scheduled for 4:10 p.m. ET; the game will be broadcast on SCHN and MLB.TV.

Houston will send Hunter Brown to the mound to take on Bryan Woo from Seattle.

Woo and the Mariners enter as -135 favorites on the moneyline, while Brown and the Astros come in at +110 to pull off the upset. Meanwhile, the over/under comes in at a low 6.5 total runs.

Find my Astros vs Mariners prediction and MLB betting preview below, as well as probable pitchers, betting trends, injury reports and more.

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• Astros vs. Mariners Pick: Bryan Woo Over 5.5 Strikeouts (-140)

My Mariners vs. Astros best bet is on Seattle pitcher Bryan Woo to go over his strikeout total. Make sure to find the best odds by checking our live MLB odds page.

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Astros vs Mariners Odds, Line, Spread

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Astros vs Mariners MLB Betting Preview

By Will Priester

Oh, how the mighty have fallen.

Houston is not the team that it once was. Additionally, I don’t see any pitchers that are afraid of this team.

Woo is on the upswing so far this season, and his K rate over the last 30 days is sitting at 31%.

I like him to pick up one at least one strikeout per inning against this team, and I think he has upside for seven or eight here. If that does happen, his over 5.5 number would cash with ease.

Pick: Bryan Woo Over 5.5 Strikeouts (-140)

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Astros vs Mariners Moneyline

I don’t have a pick on either side in this game.

Astros vs Mariners Run Line

Like the moneyline, I don’t have a bet on the run line for this Sunday afternoon matchup in the American League.

Astros vs Mariners Over/Under

I’m staying away from the game total in this one, but I do like the over on Mariners pitcher Bryan Woo’s strikeout total. I see plenty of upside for him against the Astros, so I’ll take over 5.5 Ks.

Astros vs Mariners Betting Trends to Know

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