The Chicago White Sox host the St. Louis Cardinals on on June 19, 2025. First pitch from Rate Field is scheduled for 2:10 p.m. ET; the game will be broadcast on FDSMW.
The two teams face off in Game 1 of their doubleheader on Thursday.
Find my MLB betting preview and Cardinals vs White Sox prediction below, as well as probable pitchers, betting trends, injury reports and more.
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[subheader sizedown=”false” text=”My Cardinals vs White Sox Prediction” center=”true” logo1url=”https://static.sprtactn.co/teamlogos/mlb/100/stl.png” link1=”https://www.actionnetwork.com/mlb/odds/st.-louis-cardinals” link1follow=”true” logo2url=”https://static.sprtactn.co/teamlogos/mlb/100/cws.png” link2=”https://www.actionnetwork.com/mlb/odds/chicago-white-sox” link2follow=”true”][/subheader]
- Cardinals vs White Sox pick: Erick Fedde Under 4.5 Strikeouts (-135)
My Cardinals vs White Sox best bet is on Erick Fedde under 4.5 strikeouts. Make sure to find the best odds by checking our live MLB odds page.
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Cardinals vs White Sox Odds
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Cardinals vs White Sox Projected Starting Pitchers
| Erick Fedde (STL) | Stat | Sean Burke (CHW) |
|---|---|---|
| 3-6 | W-L | 3-7 |
| 0.8 | fWAR (FanGraphs) | 0.2 |
| 3.65 / 4.98 | ERA /xERA | 4.71 / 5.45 |
| 4.13 / 4.92 | FIP / xFIP | 5.13 / 5.20 |
| 1.28 | WHIP | 1.44 |
| 5.2 | K-BB% | 6.8 |
| 40.2 | GB% | 31.8 |
| 91 | Stuff+ | 92 |
| 105 | Location+ | 99 |
Cardinals vs White Sox Prediction, Betting Analysis
Erick Fedde has had some recent success with strikeouts, but I think this is a good spot to fade him, as the 4.5 number seems to be too high.
This is a matchup against a weak White Sox lineup, but they also have several low-strikeout hitters in the lineup.
Since the start of last season, just three hitters in the projected lineup have a strikeout percentage over 22% against right-handed pitching.
The lineup is also projected to have six lefties in it, and this season, Fedde has a strikeout percentage of just 14.5% against lefties.
Pick: Erick Fedde Under 4.5 Strikeouts (-135)
Moneyline
I don’t have a moneyline play for this Cardinals vs. White Sox game.
Run Line (Spread)
I also don’t have a play on the run line for this game.
Over/Under
I’m not targeting the regular over/under, but I like Erick Fedde under 4.5 strikeouts at -135.
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Cardinals vs White Sox Betting Trends
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