The Cleveland Guardians host the Houston Astros on Friday, June 6, 2025. First pitch from Progressive Field is scheduled for 7:10 p.m. ET; the game will be broadcast on CLEG and MLB.TV.
The Astros enter as a -130 favorite on the moneyline with the over/under sitting at 8.
Find my Astros vs Guardians prediction and MLB betting preview below, as well as probable pitchers, betting trends, injury reports and more.
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- Astros vs Guardians Pick: Under 8.5
My Guardians vs. Astros best bet is on the under. Make sure to find the best odds by checking our live MLB odds page.
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Astros vs Guardians Odds, Spread, Lines
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Astros vs Guardians Projected Pitchers
| Colton Gordon (HOU) | Stat | Logan Allen (CLE) |
|---|---|---|
| 0-1 | W-L | 3-3 |
| 0.2 | fWAR (FanGraphs) | 0.5 |
| 5.95 / 2.66 | ERA /xERA | 4.22 / 4.58 |
| 4.30 / 3.70 | FIP / xFIP | 4.18 / 4.97 |
| 1.37 | WHIP | 1.59 |
| 19.5 | K-BB% | 5.9 |
| 34.9 | GB% | 42.6 |
| 97 | Stuff+ | 93 |
| 110 | Location+ | 94 |
Astros vs Guardians Pick, Best Bets
According to our system “Weather: Wind Blowing In,” this under in Astros vs. Guardians on Friday is worth a bet.
This system lights up when the wind direction is blowing in and the average speed of that wind is between 5 and 35 mph. Also, the closing total needs to be between six and 11.
With all those factors hitting the mark for this American League duel, the under is in play, especially given that this system has a 4.5% ROI and is +10,962 since its inception.
Yes, Colton Gordon (Astros) and Logan Allen (Guardians) aren’t the most reliable starting pitchers to keep this under 8.5, but weather factors should help them out here.
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Pick: Under 8.5
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Astros vs Guardians Betting Trends to Know
[bettingtrends title=”” gameid=”256081″ date=”20250606″][/bettingtrends]
[howtowatch gameid=”256081″ date=”20250606″][/howtowatch]
[subheader sizedown=”true” text=”Astros vs Guardians Weather Forecast” center=”false”][/subheader]
[gameforecast league=”mlb” gameid=”256081″ date=”20250606″][/gameforecast]
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