The Houston Astros host the Athletics on May 27, 2025. First pitch from Daikin Park is scheduled for 8:10 p.m. EDT; the game will be broadcast on SCHN.
Read our Athletics vs Astros prediction and MLB player prop home run pick below.
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- Athletics vs Astros Picks: Brent Rooker Home Run (+550, bet365)
My Athletics vs Astros best bet is on Brent Rooker to hit a home run. Make sure to find the best odds by checking our live MLB odds page.
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Athletics vs Astros Odds
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Grant Neiffer’s Athletics vs Astros Preview
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This is among the biggest mis-pricings I’ve seen this season.
Brent Rooker is among the league’s best home run hitters, and we are getting him to hit another at massive odds in an average spot.
Astros starting pitcher Hunter Brown has allowed a slightly above-average home run rate to right-handed hitters in his career. However, he grades out as a somewhat below-average matchup for right-handed power hitters.
Still, I make the fair odds on this home run prop closer to +450.
Pick: Brent Rooker Home Run (+550, bet365)
Athletics vs Astros Betting Trends
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