The Minnesota Twins host the Cleveland Guardians on May 20, 2025. First pitch from Target Field is scheduled for 7:40 p.m. ET; the game will be broadcast on CLEG and MLB.TV.
The Twins enter as -118 favorites on the moneyline with the over/under sitting at 7.5.
Read our Guardians vs Twins predictions and same-game parlay picks below.
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[subheader sizedown=”false” text=”Cleveland Guardians vs Minnesota Twins Prediction” center=”true” logo1url=”https://assets.actionnetwork.com/91388_guardians20241.png” link1=”https://www.actionnetwork.com/mlb/odds/cleveland-guardians” link1follow=”true” logo2url=”https://static.sprtactn.co/teamlogos/mlb/100/mind.png” link2=”https://www.actionnetwork.com/mlb/odds/minnesota-twins” link2follow=”true”][/subheader]
- Twins ML
- Under 7
Parlay Odds: +300 (BetMGM)
Guardians vs Twins Odds, Spread, Lines
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Guardians vs Twins Projected Pitchers
| RHP Gavin Williams (CLE) | Stat | RHP Chris Paddack (MIN) |
|---|---|---|
| 3-2 | W-L | 2-3 |
| 0.2 | fWAR (FanGraphs) | 0.3 |
| 4.29 / 5.09 | ERA /xERA | 4.05 / 4.23 |
| 4.55 / 3.76 | FIP / xFIP | 4.79 / 4.86 |
| 1.64 | WHIP | 1.18 |
| 14.4% | K-BB% | 8.3% |
| 37.5% | GB% | 38.4% |
| 102 | Stuff+ | 96 |
| 89 | Location+ | 112 |
Guardians vs Twins MLB Betting Preview
[subheader sizedown=”true” center=”false” text=”Moneyline Pick: Twins ML” logo1url=”https://static.sprtactn.co/teamlogos/mlb/100/mind.png” link1=”https://www.actionnetwork.com/mlb/odds/minnesota-twins” link1follow=”false”][/subheader]
The Twins are white hot.
They’ve won 11 of their past 12 games and are 15-6 at Target Field on the season.
Starting pitcher Chris Paddack has been reliable, and I expect him to throw a gem on Tuesday. And you don’t want to fade Minnesota’s bats right now — the Twins rank fifth among MLB lineups in wRC+ over the past two weeks (116).
[subheader sizedown=”true” center=”false” text=”Over/Under Pick: Under 7” logo1url=”https://assets.actionnetwork.com/91388_guardians20241.png” link1=”https://www.actionnetwork.com/mlb/odds/minnesota-twins” link1follow=“false” logo2url=”https://static.sprtactn.co/teamlogos/mlb/100/mind.png” link2=”https://www.actionnetwork.com/mlb/odds/minnesota-twins”][/subheader]
The total is lower than most would expect, but for good reason.
The Twins and Guardians are finishing their game from Monday, which got postponed, so both teams will be a little tired as we enter Tuesday’s match.
I expect Paddack and Cleveland starter Gavin Williams to shove in a 4-2 ballgame.
Guardians vs Twins Same-Game Parlay
- Twins ML
- Under 7
Parlay Odds: +300 (BetMGM)
Guardians vs Twins Betting Trends to Know
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[gameforecast league=”mlb” gameid=”253903″ date=”20250520″][/gameforecast]
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