MLB Best Bets, Picks & Predictions for Saturday, May 10

As always, it’s a busy Saturday in Major League Baseball with 15 games on tap, starting with Yankees vs. Athletics at Sutter Health Park.

That game features in today’s MLB best bets, with additional picks and predictions for Cubs vs. Mets and Padres vs. Rockies.

Find our three MLB best bets below, plus a best bets parlay.

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MLB Best Bets, Picks, Predictions — Saturday, May 10

Game	Time (ET)	Pick
[teammatchup link=”#1″ firstfullname=”New York Yankees” firstlogo=”https://static.sprtactn.co/teamlogos/mlb/100/nyyd.png” secondfullname=”Oakland Athletics” secondlogo=”https://static.sprtactn.co/teamlogos/mlb/100/oakd.png”][/teammatchup]	4:05 p.m.	Under 10 (-102)
[teammatchup link=”#2″ firstfullname=”Chicago Cubs” firstlogo=”https://images.actionnetwork.com/blog/2023/08/2023-mlb-logo-chicago-cubs.png” secondfullname=”New York Mets” secondlogo=”https://images.actionnetwork.com/blog/2023/08/2023-mlb-logo-new-york-mets.png”][/teammatchup]	7:15 p.m.	Mets Moneyline (-148)
[teammatchup link=”#3″ firstfullname=”San Diego Padres” firstlogo=”https://static.sprtactn.co/teamlogos/mlb/100/sd.png” secondfullname=”Colorado Rockies” secondlogo=”https://static.sprtactn.co/teamlogos/mlb/100/col.png”][/teammatchup]	8:10 p.m.	Padres Run Line -1.5 (-150)
Specific betting recommendations come from the sportsbook offering preferred odds as of writing. Always shop for the best price using our MLB Odds page, which automatically surfaces the best lines for every game.

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[anchor name=”1″][/anchor]

[subheader sizedown=”false” text=”Justin Van Zuiden’s Yankees vs Athletics Over/Under Prediction”][/subheader]

[gameheader haspick=”true” picktext=”Under 10 (-115)” league=”mlb” awaylogo=”https://static.sprtactn.co/teamlogos/mlb/100/nyyd.png” awayname=”New York Yankees” awayslug=”new-york-yankees” homelogo=”https://static.sprtactn.co/teamlogos/mlb/100/oakd.png” homename=”Oakland Athletics” homeslug=”oakland-athletics” date=”Saturday, May 10″ time=”4:05 p.m. ET” network=”MLB Network” bookname=”BetMGM” bookprimarylogo=”https://assets.actionnetwork.com/779359_BetMGM800x200@1x.png” bookreviewslug=”betmgm”][/gameheader]

By Justin Van Zuiden

I know Sutter Health Park has a great run-scoring environment and that Aaron Judge and the Yankees are dangerous with the bats, but I am shocked to see this total sitting at 10 runs.

Carlos Rodon is every bit of an elite pitcher when his command is not off, and he has a 30%+ strikeout rate so far in 2025.

Athletics starter JP Sears is not a gas can on the other side, either, and he has shown solid stuff in 2025.

I can’t see this game getting off the rails for a ton of runs and will back the under on a big number.

Pick: Under 10 (-115)

[relatedarticle articleimageurl=”https://images.actionnetwork.com/blog/2025/05/rodoncarl0510.jpg” linktext=”Yankees vs Athletics Prediction, Pick, Odds for Saturday, May 10″ link=”https://www.actionnetwork.com/mlb/new-york-yankees-vs-athletics-prediction-pick-odds-saturday-may-10-qs”][/relatedarticle]

[teammatchup link=”#1″ shadow=”true” firstfullname=”New York Yankees” firstlogo=”https://static.sprtactn.co/teamlogos/mlb/100/nyyd.png” secondfullname=”Oakland Athletics” secondlogo=”https://static.sprtactn.co/teamlogos/mlb/100/oakd.png”][/teammatchup]

[teammatchup link=”#2″ shadow=”true” firstfullname=”Chicago Cubs” firstlogo=”https://images.actionnetwork.com/blog/2023/08/2023-mlb-logo-chicago-cubs.png” secondfullname=”New York Mets” secondlogo=”https://images.actionnetwork.com/blog/2023/08/2023-mlb-logo-new-york-mets.png”][/teammatchup]

[teammatchup link=”#3″ shadow=”true” firstfullname=”San Diego Padres” firstlogo=”https://static.sprtactn.co/teamlogos/mlb/100/sd.png” secondfullname=”Colorado Rockies” secondlogo=”https://static.sprtactn.co/teamlogos/mlb/100/col.png”][/teammatchup]

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[subheader sizedown=”false” text=”Justin Van Zuiden’s Cubs vs Mets Moneyline Pick”][/subheader]

[gameheader haspick=”true” picktext=”Mets Moneyline (-148)” league=”mlb” awaylogo=”https://images.actionnetwork.com/blog/2023/08/2023-mlb-logo-chicago-cubs.png” awayname=”Chicago Cubs” awayslug=”chicago-cubs” homelogo=”https://images.actionnetwork.com/blog/2023/08/2023-mlb-logo-new-york-mets.png” homename=”New York Mets” homeslug=”new-york-mets” date=”Saturday, May 10″ time=”7:15 p.m. ET” network=”FOX” bookname=”FanDuel” bookprimarylogo=”https://assets.actionnetwork.com/122955_FanDuelSportsBook@1x.jpg” bookreviewslug=”fanduel”][/gameheader]

By Justin Van Zuiden

I love this spot for the Mets; I had this line pegged at closer to -180.

Tylor Megill has a sub-3.00 ERA and very strong advanced metrics that include a 29% strikeout rate. The Cubs have been in a bit of a funk this week, and I like Megill’s chances of keeping that going.

Meanwhile, the Cubs are replacing Shota Imanaga in their rotation due to injury and are using Brad Keller as an opener followed by the major-league debut of Cade Horton.

It just doesn’t project well against an elite offense — thus, I’ll back the Mets to win this evening.

Pick: Mets Moneyline (-148)

[relatedarticle articleimageurl=”https://images.actionnetwork.com/blog/2025/05/kyletucker510.jpg” linktext=”Cubs vs Mets Prediction, Pick, Odds for Saturday, May 10″ link=”https://www.actionnetwork.com/mlb/chicago-cubs-vs-new-york-mets-prediction-pick-odds-saturday-may-10-qs”][/relatedarticle]

[anchor name=”3″][/anchor]

[subheader sizedown=”false” text=”Brit Devine’s Padres vs Rockies Spread Prediction”][/subheader]

[gameheader haspick=”true” picktext=”Padres Run Line -1.5 (-150)” league=”mlb” awaylogo=”https://static.sprtactn.co/teamlogos/mlb/100/sd.png” awayname=”San Diego Padres” awayslug=”san-diego-padres” homelogo=”https://static.sprtactn.co/teamlogos/mlb/100/col.png” homename=”Colorado Rockies” homeslug=”colorado-rockies” date=”Saturday, May 10″ time=”8:10 p.m. ET” network=”MLB.TV” bookname=”bet365″ bookprimarylogo=”https://assets.actionnetwork.com/859377_Bet365@1x.png” bookreviewslug=”bet365″][/gameheader]

By Brit Devine

The Rockies have lost 32 games this season; they have lost by just a single run in only three of those games.

They have a run differential of -113, dead last in the league. The next-worst team has a run differential of -69. The Rockies are teetering on being a historically bad team.

I see no reason to bet on any teams’ moneyline against them as we get better odds with little difference in outcome by taking the run line.

The Padres‘ offense is at full strength, and just like last night when I won this bet, I expect them to cruise to a victory.

I’m betting to win 2 units.

Pick: Padres Run Line -1.5 (-150)

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