Orioles vs Twins Prediction, Pick, Odds for Tuesday, May 6

The Minnesota Twins host the Baltimore Orioles on May 6, 2025. First pitch from Target Field is scheduled for 7:40 p.m. ET; the game will be broadcast on MASN and MLB.TV.

The Twins enter as -175 favorites on the moneyline with the over/under sitting at 8.5.

Find my Orioles vs Twins prediction and MLB betting preview below, as well as probable pitchers, betting trends, injury reports and more.

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• Orioles vs Twins Pick: Byron Buxton Over 1.5 Total Bases

My Orioles vs Twins best bet is Minnesota outfielder Byron Buxton to go over 1.5 total bases. Make sure to find the best odds by checking our live MLB odds page.

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Orioles vs Twins Odds

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Orioles vs Twins MLB Betting Preview

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By Chris Prince

I absolutely love this spot for Byron Buxton and the Twins tonight against Baltimore left-hander Cade Povich.

Buxton has always hit left-handed pitching well, and he’s off to a torrid pace to start this season, amassing a .467 wOBA to go along with a huge .364 ISO. He can easily smash this prop with one swing of the bat.

He has racked up five multi-hit games over his last nine and has covered this six times over that span.

Povich has really struggled with righties, allowing a .443 wOBA, a .269 ISO and a 56% hard contact rate this season. He carries an ugly 6.07 ERA and 1.69 WHIP into tonight.

I’m backing Buxton to go over his total bases prop tonight.

Pick: Byron Buxton Over 1.5 Total Bases

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Orioles vs Twins Betting Trends

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