mlb-odds-moneyline-home-run-picks-4-21-2025

MLB Odds: Moneyline Picks, Home Run Predictions, Strikeout Props for 4/21

As we delve into MLB Monday, with its limited slate of games, bettors can look forward to an exciting array of picks across various categories.

Whether you’re seeking moneyline picks, home run predictions, or strikeout props, we’ve got you covered.

A crucial component of these decisions comes from the insights provided by our proprietary betting data, known as PRO Projections.

Our team of experts meticulously analyzes MLB odds, player projections and more to identify betting edges within the market. Also, we’ve tracked sharp action and big bets landing on a side. In total, we present three distinctive picks tonight, featuring one from each category.

The action begins at 6:40 p.m. ET, so let’s dive into the details.


MLB Odds, Picks for 4/21

Moneyline Predictions

Starting with our first moneyline pick, we focus on the showdown between the Toronto Blue Jays and the Houston Astros.

With MLB odds listing the Astros at -135 and the Blue Jays at +115, smart money is flooding in on Toronto. Behind the prowess of starting pitcher Kevin Gausman, PRO Report has observed significant bets and calculated sharp action favoring the underdog, resulting in a one-sided stance on the Blue Jays moneyline.

This sentiment is echoed by top experts using the Action App, who also back Toronto for this matchup, drawing the Astros fresh off Sunday Night Baseball.

PRO Pick: Blue Jays Moneyline


Home Run Predictions

Moving on to our choice for the best home run picks, Pete Alonso, in the Phillies vs. Mets game, is PRO Projections’ largest edge. Alonso offers a tantalizing opportunity at +450 odds, with our projections forecasting 0.30 home runs, representing a 4% edge over the current market projections.

PRO Pick: Pete Alonso Home Run (+450)


Strikeout Props

Lastly, we examine the top strikeout prop for the day in the clash between the San Diego Padres and Detroit Tigers. The spotlight is on the Padres’ starting pitcher, Randy Vasquez, with a strikeout line set at under 3.5, and odds of -120 available at DraftKings.

Our PRO Projections estimate his strikeouts at 3.2, providing a solid edge on the under tonight.

PRO Pick: Randy Vazquez Under 3.5 Strikeouts

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Our PRO signals flag far more great picks than our staff could author each day — that’s where Action AI comes in. Using generative AI, signals that hit a high grade threshold are written up into articles that are then vetted and edited by a human to help us get you all the sharp action. Read more about how it works here.


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