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NFL Week 4 Predictions, Spread and Over/Under Picks

We’re utilizing PRO Systems and sharp insights from PRO Report to find the best NFL Week 4 predictions. It’s early in the betting market cycle, but here are some goodies to consider.

We’ve already tracked sharp action, big money, and top experts taking advantage of an over/under pick which is potentially off price. Additionally, another spread that fits a sweet situational angle.

Here are a couple of sharp picks for bettors in Week 4.


NFL Week 4 Predictions, Spread and Over/Under Picks

PRO Systems can build endless betting trends that are reliable for making informed decisions.

For Sunday’s Week 4 card, one noteworthy PRO System banks on fading the public after a team plays poorly. Basically, there’s a Week 4 spread nobody wants anything to do with — likely because of how the team performed this past week.

This system boasts an impressive record, having cashed 61% of spread predictions.

Last week, this PRO System nailed both of its picks: the Panthers and the Broncos against the spread, both of which won outright.


Eagles vs. Buccaneers Prediction for Week 4

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Let’s start with the Eagles vs. Buccaneers game, teed up for a hot situational spot.

The Eagles are currently favored by -2.5 points. Neither team played particularly well last week, but there is a solid angle to exploit here, thanks to our PRO Systems.

In this matchup, the PRO System indicates a pick on the Buccaneers against the spread.

Tampa Bay only managed 7 points in last week’s loss to the Broncos. The “Fade the Public After Bad Game” PRO System is straightforward and based on historical data.

When teams are off a game in which they scored single digits and are attracting less than 30% of the tickets in our trackers, they’ve managed to cover the spread 61% of the time in the subsequent game.

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Essentially, when the public is heavily against a side recovering from a poor offensive performance, this system suggests it’s usually the right side to back.

Our sharp-action signal is also live on the Buccaneers, plus the points!

This is one of our sharp NFL Week 4 predictions, as the Buccaneers +2.5 is backed by multiple key insights.

PRO System Pick: Buccaneers ATS


Steelers vs. Colts Prediction for Week 4

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Switching gears to the smart over/under pick, we find an intriguing play in the Steelers vs. Colts game. The over/under is set at 41 points.

Our latest data tracks sharp action, big money, and top experts in our app are all aligned on the under, making it the strongest early pick of the week.

All three Steelers games have notably gone under the total out of the gates.

PRO Report Pick: Steelers vs. Colts Under


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Our PRO signals flag far more great picks than our staff could author each day — that’s where Action AI comes in. Using generative AI, signals that hit a high grade threshold are written up into articles that are then vetted and edited by a human to help us get you all the sharp action. Read more about how it works here.